Supernatural is a live action TV series created by Eric Kripke, starring Jared Padalecki and Jensen Ackles, beginning in 2005 and still running to this day.
- 1 Season 1
- 1.1 Pilot
- 1.2 Wendigo
- 1.3 Dead in the Water
- 1.4 Phantom Traveler
- 1.5 Bloody Mary
- 1.6 Skin
- 1.7 Hook Man
- 1.8 Bugs
- 1.9 Home
- 1.10 Asylum
- 1.11 Scarecrow
- 1.12 Faith
- 1.13 Route 666
- 1.14 Nightmare
- 1.15 The Benders
- 1.16 Shadow
- 1.17 Hell House
- 1.18 Something Wicked
- 1.19 Provenance
- 1.20 Dead Man's Blood
- 1.21 Salvation
- 1.22 Devil's Trap
- 2 Season 2
- 2.1 In My Time of Dying
- 2.2 Everybody Loves a Clown
- 2.3 Bloodlust
- 2.4 Children Shouldn't Play with Dead Things
- 2.5 Simon Said
- 2.6 No Exit
- 2.7 The Usual Suspects
- 2.8 Crossroad Blues
- 2.9 Croatoan
- 2.10 Hunted
- 2.11 Playthings
- 2.12 Nightshifter
- 2.13 Houses of the Holy
- 2.14 Born Under a Bad Sign
- 2.15 Tall Tales
- 2.16 Roadkill
- 2.17 Heart
- 2.18 Hollywood Babylon
- 2.19 Folsom Prison Blues
- 2.20 What Is and What Should Never Be
- 2.21 All Hell Breaks Loose Part 1
- 2.22 All Hell Breaks Loose Part 2
- 3 Season 3
- 3.1 The Magnificent Seven
- 3.2 The Kids Are Alright
- 3.3 Bad Day at Black Rock
- 3.4 Sin City
- 3.5 Bedtime Stories
- 3.6 Red Sky at Morning
- 3.7 Fresh Blood
- 3.8 A Very Supernatural Christmas
- 3.9 Malleus Maleficarum
- 3.10 Dream a Little Dream of Me
- 3.11 Mystery Spot
- 3.12 Jus in Bello
- 3.13 Ghostfacers
- 3.14 Long Distance Call
- 3.15 Time is on My Side
- 3.16 No Rest for the Wicked
- 4 Season 4
- 4.1 Are You There, God? It's Me, Dean Winchester
- 4.2 In the Beginning
- 4.3 Metamorphosis
- 4.4 Monster Movie
- 4.5 Yellow Fever
- 4.6 It's the Great Pumpkin, Sam Winchester
- 4.7 Wishful Thinking
- 4.8 I Know What You Did Last Summer
- 4.9 Heaven and Hell
- 4.10 Family Remains
- 4.11 Criss Angel is a Douche Bag
- 4.12 After School Special
- 4.13 Sex and Violence
- 4.14 Death Takes a Holiday
- 4.15 On the Head of a Pin
- 4.16 It's a Terrible Life
- 4.17 Jump the Shark
- 4.18 The Rapture
- 4.19 Lucifer Rising
- 5 Season 5
- 5.1 Sympathy for the Devil
- 5.2 Good God, Y'All
- 5.3 Fallen Idols
- 5.4 I Believe the Children Are Our Future
- 5.5 The Curious Case of Dean Winchester
- 5.6 Changing Channels
- 5.7 The Real Ghostbusters
- 5.8 Abandon All Hope...
- 5.9 Sam, Interrupted
- 5.10 Swap Meat
- 5.11 The Song Remains the Same
- 5.12 My Bloody Valentine
- 5.13 Dead Men Don't Wear Plaid
- 5.14 Dark Side of the Moon
- 5.15 99 Problems
- 5.16 Point of No Return
- 5.17 Hammer of the Gods
- 5.18 The Devil You Know
- 5.19 Two Minutes to Midnight
- 5.20 Swan Song
- 5.21 Notes
- 6 Season 6
- 6.1 Exile on Main St.
- 6.2 Two and a Half Men
- 6.3 The Third Man
- 6.4 Weekend at Bobby's
- 6.5 Live Free or Twihard
- 6.6 You Can't Handle the Truth
- 6.7 Family Matters
- 6.8 All Dogs Go To Heaven
- 6.9 Clap Your Hands If You Believe...
- 6.10 Caged Heat
- 6.11 Appointment in Samarra
- 6.12 Like a Virgin
- 6.13 Unforgiven
- 6.14 Mannequin 3: The Reckoning
- 6.15 The French Mistake
- 6.16 ...And Then There Were None
- 6.17 My Heart Will Go On
- 6.18 Frontierland
- 6.19 Mommy Dearest
- 6.20 The Man Who Would Be King
- 6.21 Let It Bleed
- 6.22 The Man Who Knew Too Much
- 7 Season 7
- 7.1 Meet the New Boss
- 7.2 Hello, Cruel World
- 7.3 The Girl Next Door
- 7.4 Defending Your Life
- 7.5 Shut Up, Dr. Phil
- 7.6 Slash Fiction
- 7.7 The Mentalists
- 7.8 Season Seven, Time for a Wedding!
- 7.9 How to Win Friends and Influence Monsters
- 7.10 Death's Door
- 7.11 Adventures in Babysitting
- 7.12 Time after Time
- 7.13 The Slice Girls
- 7.14 Plucky Pennywhistle's Magical Menagerie
- 7.15 Repo Man
- 7.16 Out with the Old
- 7.17 The Born-Again Identity
- 7.18 Party On, Garth
- 7.19 Of Grave Importance
- 7.20 The Girl with the Dungeons and Dragons Tattoo
- 7.21 Reading is Fundamental
- 7.22 Survival of the Fittest
- 8 Season 8
- 8.1 We Need To Talk About Kevin
- 8.2 What's Up, Tiger Mommy?
- 8.3 Heartache
- 8.4 Bitten
- 8.5 Blood Brother
- 8.6 Southern Comfort
- 8.7 A Little Slice of Kevin
- 8.8 Hunteri Heroici
- 8.9 Citizen Fang
- 8.10 Torn and Frayed
- 8.11 LARP and the Real Girl
- 8.12 As Time Goes By
- 8.13 Everybody Hates Hitler
- 8.14 Trial and Error
- 8.15 Man's Best Friend with Benefits
- 8.16 Remember the Titans
- 8.17 Goodbye Stranger
- 8.18 Freaks and Geeks
- 8.19 Taxi Driver
- 8.20 Pac-Man Fever
- 8.21 The Great Escapist
- 8.22 Clip Show
- 9 Season 9
- 9.1 I Think I'm Gonna Like It Here
- 9.2 Devil May Care
- 9.3 I'm No Angel
- 9.4 Slumber Party
- 9.5 Dog Dean Afternoon
- 9.6 Heaven Can't Wait
- 9.7 Bad Boys
- 9.8 Rock and a Hard Place
- 9.9 Holy Terror
- 9.10 Road Trip
- 9.11 First Born
- 9.12 Sharp Teeth
- 9.13 The Purge
- 9.14 Captives
- 9.15 #THINMAN
- 9.16 Blade Runners
- 9.17 Mother's Little Helper
- 9.18 Alex Annie Alexis Ann
- 9.19 Bloodlines
- 9.20 King of the Damned
- 9.21 Stairway to Heaven
- 9.22 Do You Believe in Miracles?
- 10 Season 10
- 10.1 Black
- 10.2 Reichenbach
- 10.3 Soul Survivor
- 10.4 Paper Moon
- 10.5 Fan Fiction
- 10.6 Ask Jeeves
- 10.7 Girls, Girls, Girls
- 10.8 Hibbing 911
- 10.9 The Things We Left Behind
- 10.10 The Hunter Games
- 10.11 There's No Place Like Home
- 10.12 About a Boy
- 10.13 Halt & Catch Fire
- 10.14 The Executioner's Song
- 10.15 The Things They Carried
- 10.16 Paint it Black
- 10.17 Inside Man
- 10.18 Book of the Damned
- 10.19 The Werther Project
- 10.20 Angel Heart
- 10.21 Dark Dynasty
- 10.22 The Prisoner
- 10.23 Brother's Keeper
- 11 Season 11
- 11.1 Out of the Darkness, Into the Fire
- 11.2 Form and Void
- 11.3 The Bad Seed
- 11.4 Baby
- 11.5 Thin Lizzie
- 11.6 Our Little World
- 11.7 Plush
- 11.8 Just My Imagination
- 11.9 O Brother Where Art Thou?
- 11.10 The Devil in the Details
- 11.11 Into the Mystic
- 11.12 Don't You Forget About Me
- 11.13 Love Hurts
- 11.14 The Vessel
- 11.15 Beyond the Mat
- 11.16 Safe House
- 11.17 Red Meat
- 11.18 Hell's Angel
- 11.19 The Chitters
- 11.20 Don't Call Me Shurley
- 11.21 All in the Family
- 11.22 We Happy Few
- 12 Season 12
- 12.1 Keep Calm and Carry On
- 12.2 The Foundry
- 12.3 American Nightmare
- 12.4 The One You've Been Waiting For
- 12.5 Celebrating the Life of Asa Fox
- 12.6 Rock Never Dies
- 12.7 LOTUS
- 12.8 First Blood
- 12.9 Lily Sunder Has Some Regrets
- 12.10 Regarding Dean
- 12.11 Stuck in the Middle (With You)
- 12.12 Family Feud
- 12.13 The Raid
- 12.14 Somewhere Between Heaven and Hell
- 12.15 Ladies Drink Free
- 12.16 The British Invasion
- 12.17 The Memory Remains
- 12.18 The Future
- 12.19 Twigs & Twine & Tasha Banes
- 12.20 There's Something About Mary
- 12.21 Who We Are
- 12.22 All Along the Watchtower
- 13 Season 13
- 13.1 Lost and Found
- 13.2 The Rising Son
- 13.3 Patience
- 13.4 The Big Empty
- 13.5 Advanced Thanatology
- 13.6 Tombstone
- 13.7 The Scorpion and the Frog
- 13.8 The Bad Place
- 13.9 Wayward Sisters
- 13.10 Breakdown
- 13.11 Various & Sundry Villains
- 13.12 Good Intentions
- 13.13 A Most Holy Man
- 13.14 ScoobyNatural
- 13.15 The Thing
- 13.16 Bring 'em Back Alive
- 13.17 Funeralia
- 13.18 Unfinished Business
- 13.19 Beat the Devil
- 13.20 Exodus
- 13.21 Let the Good Times Roll
- 14 Season 14
- 14.1 Stranger in a Strange Land
- 14.2 Gods and Monsters
- 14.3 The Scar
- 14.4 Mint Condition
- 14.5 Nightmare Logic
- 14.6 Optimism
- 14.7 Unhuman Nature
- 14.8 Byzantium
- 14.9 The Spear
- 14.10 Nihilism
- 14.11 Damaged Goods
- 14.12 Prophet and Loss
- 14.13 Lebanon
- 14.14 Ouroboros
- 14.15 Peace of Mind
- 14.16 Don't Go in the Woods
- 14.17 Game Night
- 14.18 Jack in the Box
- 14.19 Moriah
- 15 Season 15
- 15.1 Back and to the Future
- 15.2 Raising Hell
- 15.3 The Rupture
- 15.4 Atomic Monsters
- 15.5 Proverbs 17:3
- 15.6 Golden Time
- 15.7 Last Call
- 15.8 Our Father, Who Aren't In Heaven
- 15.9 The Trap
- 15.10 The Heroes' Journey
- 15.11 The Gamblers
- 15.12 Galaxy Brain
- 15.13 Destiny's Child
- 15.14 Gimme Shelter
- 15.15 Drag Me Away (From You)
- 15.16 Despair
- 15.17 Inherit the Earth
- 15.18 Carry On
- 16 Deaths
- 17 Kill Counts
- Mary Winchester - Pinned to the ceiling by Azazel, sliced open, and set on fire. Later returned as a ghost to destroy a poltergeist. Resurrected by Amara in the Season 11 finale.
- Poltergeist from Amherst - He was briefly mentioned by Sam, indicating that he was destroyed off-screen.
- Ten Unknown Men - Killed off-screen by Woman in White (mentioned).
- Troy Squire - Killed offscreen by the Woman in White.
- Woman in White (Constance Welch's Spirit) - Destroyed by the spirits of her children whom she killed.
- Constance Welch Son and Daughter's Spirits - Entered the afterlife after destroying their mother.
- Jessica Moore - Pinned to the ceiling by Brady, sliced open, and set on fire. Azazel told him to kill her to get Sam back into hunting, and make it seem like Azazel killed her, likely so his attack would be recognized.
- Several Unknown People - Eaten by Colorado Wendigo during his 2 other attacks : one in 1936 and another in 1982.
- Shaw's Father - Eaten by Colorado Wendigo (mentioned).
- Shaw's Mother - Eaten by Colorado Wendigo (mentioned).
- Brad - Presumably eaten by Colorado Wendigo.
- Gary - Eaten by Colorado Wendigo.
- Roy - Neck broken by Colorado Wendigo.
- Colorado Wendigo - Shot by Dean with a flare gun, burning it to a crisp.
Dead in the Water
- Sophie Carlton - Drowned by the Spirit of Peter Sweeney.
- Will Carlton - Drowned by the Spirit of Peter Sweeney, when he pulled his head below the surface of the water in the kitchen sink.
- Bill Carlton - Boat blown up by the spirit of Peter Sweeney, while he was on it.
- Sheriff Jake Devins - Offered himself to the spirit of Peter Sweeney (as he and Bill accidentally drowned him), who then drowned him.
- Peter Sweeney's Vengeful Spirit - Put to rest after killing his killers.
- George Phelps - Possessed by a demon, who opened the door of the plane to suck most of the passengers out.
- Chuck Lambert - Possessed by the demon, who crashed the plane.
- Steven Shoemaker - Killed by Bloody Mary in front of the mirror, making his eyes bleed until he was dead.
- Jill - Killed by Bloody Mary in front of the mirror, making her eyes bleed until she was dead.
- Bloody Mary (Mary Worthington's Spirit) - Shown her own reflection in a mirror by Dean, who then shattered the mirror.
- Emily - Beaten to death offscreen by a shapeshifter impersonating Zach.
- Unnamed Woman - Tortured and killed by the shapeshifter, who was impersonating her husband.
- Unnamed Shapeshifter - Shot in the heart by Dean with a silver bullet.
- Rich - Killed offscreen by the Hookman.
- Taylor - Killed offscreen by the Hookman.
- Hookman (Jacob Karns's Violent Spirit) - Destroyed when the necklace that his silver hook was made into (therefore his only remains) was thrown into the furnace by Dean.
- Dustin Burwash - Killed by beetles, under a curse.
- Lynda Bloome - Killed by spiders, under a curse, and fell through the glass door of her shower.
- Unnamed Plumber - Killed by the poltergeist.
- Unnamed Poltergeist - Destroyed by the Spirit of Mary Winchester.
- Mary Winchester's Spirit - Vanished in a ball of flame destroying the poltergeist, to go on to the next world. Presumably Heaven, although Ash has not yet found her there. She was later revived by Amara.
- Walter Kelly's Wife - Shot by Walter, who was driven insane by the spirit of Dr. Ellicott.
- Walter Kelly - Shot himself to the head after being driven insane by the spirit of Dr. Ellicott.
- Dr. Sanford Ellicott's Violent Spirit - Destroyed when his remains were burned by Dean.
- Vince - Mutilated offscreen by Vanir as a sacrifice.
- Holly - Killed offscreen by Vanir
- Unnamed Van Driver - Killed offscreen by Meg, possibly slitting his throat to communicate with Azazel.
- Harley Jorgeson - Stabbed by Vanir and taken away as a sacrifice.
- Stacy Jorgeson - Dragged away and killed offscreen by Vanir as a sacrifice.
- Vanir - Killed when Emily burned the First Tree, the source of its power.
- Unnamed Truck Driver - Throat slit by Meg so she could use his blood and communicate with Azazel.
- Unnamed Rawhead - Electrocuted by Dean with a taser, as it was standing in a puddle of water.
- Marshall Hall - Died of a heart attack caused by a Reaper, under Sue Ann's control, healing Dean of the heart attack and making Marshall die of it instead.
- Sue-Ann Le Grange - Killed by the Reaper, which was released from her control when Sam destroyed her altar and cross.
- Layla Rourke - Presumably dies of a brain tumor, but accepts this at the end of the episode, though her death is never seen or mentioned after the episode.
- Clayton Solmes - Killed when Cyrus's spirit, driving a truck, caused his car to crash off the road, offscreen. This was revenge for his death.
- Martin Robinson - Killed when Cyrus's spirit, driving a truck, caused his car to crash off the road. This was revenge for his death.
- Jimmy Anderson - Killed when Cyrus's spirit, driving a truck, caused his car to crash off the road. This was revenge for his death.
- Harold Todd - Run over by Cyrus's spirit with his truck. This was revenge for not doing anything about his death (as Todd knew the horrible things Cyrus had done).
- Cyrus Dorian's Vengeful Spirit - Tricked by Dean, under directions from Sam, into driving his truck onto a spot where a church once stood (which Cyrus himself burned down), and this destroyed him.
- Jim Miller - Trapped inside his car inside the garage by Max with his telekinetic powers, causing him to die of monoxide poisoning. This was revenge for physically abusing him.
- Roger Miller - Decapitated by Max as revenge for physically abusing him.
- Max Miller - Used his telekinetic powers to shoot himself in the head with a gun.
- Alvin Jenkins - Stabbed offscreen by two of the Benders with knives.
- Pa Bender - Wounded by Sam, then shot by Kathleen because he was taunting her about how he killed her brother.
- Meredith - Torn apart by a Daeva, under Meg's control.
- Girl - Killed offscreen by Mordechai Murdoch.
- Mordechai Murdoch (Tulpa) - House was burned down, and because the house part of the legend didn't exist anymore, neither did he, since he was a manifestation of what people believed about the legend due to a symbol painted on the house.
- Dr. Hydecker (Shtriga) - Shot between the eyes by Dean with an iron round while trying to eat Sam's energy.
- Anne Telesca - Throat slashed offscreen by the spirit of Melanie Merchant.
- Mark Telesca - Throat slashed offscreen by the spirit of Melanie Merchant.
- Isaiah Merchant - Is said to have slit his own throat after doing the same to his wife and kids, long before the events of the episode.
- Evelyn - Throat slashed offscreen by the spirit of Melanie Merchant.
- Melanie Merchant's Violent Spirit - Was destroyed when Dean burned an antique doll that had some of her hair on it.
Dead Man's Blood
- Daniel Elkins - Killed offscreen by Kate and the other vampires, presumably by sucking his blood or stabbing him with a knife.
- Hank - Decapitated by John with a machete.
- Bo - Decapitated by Dean.
- Luther - Shot in the head by John with the Colt.
- Pastor Jim Murphy - Throat slit by Meg.
- Caleb - Throat slit by Meg.
- Meg Masters (human) - Died painfully after the demon Meg was exorcised from her, as she was thrown from a window and also shot.
- Tom (Black-Eyed Demon) - Shot in the head by Dean with Colt.
- Tom's Vessel - Shot in the head by Dean with Colt.
In My Time of Dying
- John Winchester - Killed offscreen by Azazel as part of a deal to heal Dean from a mortal injury. He went to Hell, but later escaped and presumably went to Heaven, although Ash has not found him there yet.
Everybody Loves a Clown
- Rakshasa - Stabbed from behind by Sam with the brass pipe from an organ.
- Vampire - Decapitated by Gordon.
- Conrad - Decapitated by Dean with an electric saw.
Children Shouldn't Play with Dead Things
- Angela Mason - Crashed her car, not noticing a turn on the road.
- Matt - Throat slit offscreen by the Angela zombie.
- Neil - Neck snapped by the Angela zombie.
- Angela Mason zombie - Stabbed inside her coffin by Dean with a stake.
- Dr. Jennings - Walked straight into a bus, under mind control by Ansem.
- Holly Beckett - Mind controlled by Ansem to douse herself in gasoline and set herself on fire.
- Ansem Weems - Shot by Andy as he was about to make Dean kill himself.
- Bill Harvelle - Long before events of the show, is said to have been badly injured by some kind of hell spawn, begging John to shoot him, so he did.
The Usual Suspects
- Tony Giles - Killed offscreen by Pete.
- Karen Giles - Killed offscreen by Pete.
- Pete Sheridan - Shot by Diana while he was about to shoot Dean.
- Robert Johnson - Several years before the events of the episode, as shown in the intro, made a deal with a crossroads demon, and was killed by hellhounds and went to hell. His injuries were inflicted offscreen.
- Dr. Silvia Pearlman - Made a deal with a crossroads demon ten years ago, and after those ten years was killed by hellhounds sent by the demons, and went to hell.
- George Darrow - Though never seen, he was presumably killed by the Hellhounds because he made a deal with a crossroads demon ten years ago, and went to hell after death.
- Mr. Tanner - Infected by Croatoan virus, and then shot three times in the chest by Dean.
- Mr. Rogers - Never seen, but mentioned to be killed by Mark as he was infected by Croatoan virus.
- Beverly Tanner - Infected by Croatoan virus, then shot twice by Dean.
- Nurse Pamela - Infected by Croatoan virus and while trying to infect Sam as well, was shot in the back three times by Dean.
- Mark - Throat slit by a demon that was possessing Duane.
- Scott Carey - Stabbed twice by Gordon, as he was out to kill everyone with psychic abilities due to Azazel's plans for them.
- Brady (Ava's fiance) - Throat slit offscreen, presumably by a demon.
- Man - Head twisted by Maggie's spirit with a voodoo doll.
- Lawyer - Hung by the neck on the ceiling fan by Maggie using voodoo.
- Rose - Traded her life for Tyler's, so she could remain with Maggie as a spirit.
- Edgar - Is mentioned to be shot in the face by a shapeshifter impersonating Helena.
- Helena - Is mentioned to be killed when the shapeshifter dropped a hairdryer in the bathtub to electrocute her, making it seem a suicide.
- Ron Reznick - Shot by a police sniper, as he was mistaken for robbing a bank due to acting like one while trying to hunt down the shapeshifter.
- Shapeshifter - Stabbed by Dean with a silver blade.
Houses of the Holy
- Carl Gully - Killed offscreen by Gloria, who was told by the spirit of Father Gregory (who believes he is an angel) to do so.
- Frank - Killed by Zach because Father Gregory's spirit told him to do so.
- Father Gregory spirit - Disappeared at rest when Father Reynolds said the last rites.
- Would-be rapist - While being chased by Dean in his car, was impaled by a falling thin metal pipe from a truck they nearly collided with. Dean believed that this indeed was the will of God.
Born Under a Bad Sign
- Steve Wandell - Throat slit by Meg, who was possessing Sam.
- Professor Cox - Jumped from a window, as part of an urban legend by Gabriel (the Trickster) when he created an illusion of a girl who also jumped from the window and was now dead.
- Scientist - Killed by an alligator in the sewers. The giant alligator was created by Gabriel as part of an urban legend.
- Molly McNamara - Crashed her car while unsuccessfully trying to avoid Greely.
- Jonah Greely - Accidentally hit by Molly with her car.
- Jonah Greely's spirit - Destroyed when Sam burned his corpse.
- Lawyer - Killed by Madison (as a werewolf), mauled to death and heart taken out.
- Kurt - Killed offscreen by Madison as a werewolf, mauled to death and heart taken out.
- Glen - Shot by Dean with a silver bullet. Was in werewolf form at the time.
- Madison - Shot by Sam, telling him to kill her so she wouldn't kill anyone else the next time she turned into a werewolf.
- Brad Redding - Hanged by spirits that were under Walter's control.
- Jay - Dragged into a giant fan by a ghost (under Walter's control) and sliced to pieces.
- Walter Dixon - Destroyed the talisman he used to control the spirits, unwittingly releasing them from his control, and they tore him apart as revenge for controlling them.
Folsom Prison Blues
- Lucas - Killed offscreen by the spirit of Nurse Glockner.
- Mark Moody - Long before the events of the episode, is said to have been brutally beat by the prison guards and suffered a heart attack.
- Tiny - Killed offscreen by the spirit of Nurse Glockner.
- Nurse Glockner spirit - Was destroyed when Sam and Dean burned her remains.
What Is and What Should Never Be
- Djinn - Stabbed by Dean with a knife.
All Hell Breaks Loose Part 1
- Lily - Killed offscreen by a demon summoned by Ava, then hung from a water tower.
- Ash - Among others in the Roadhouse, was killed when demons (either working for Azazel or Azazel himself) burned it down. Confirmed in Season 5 as he turns up in heaven.
- Andy Gallagher - Mauled to death by a demon summoned by Ava.
- Ava Wilson - Neck snapped by Jake, breaking her control over the demon.
- Sam Winchester - Stabbed in the back by Jake with a knife. Afterward Dean made a deal with a crossroads demon to bring him back to life, on the condition that Dean go to hell in a year.
All Hell Breaks Loose Part 2
- Jake Talley - Shot multiple times by Sam right after opening Hell's Gate. Jake survived the first few shots, but was shot several times again by Sam, killing him in a cold way Sam would not have done before his death and resurrection.
- Azazel - Shot in the heart by Dean with the Colt.
The Magnificent Seven
- Three people - Under influence of Sloth, stayed in front of the TV and died of starvation.
- Woman - Head smashed against a windshield (causing her eye to gouge out) by another woman who was under Envy's influence and wanted her shoes.
- Isaac - Under influence of Gluttony, drank drain cleaner. His body was later possessed by Wrath.
- Walter - Died of unknown causes after Envy was exorcised from him.
- Gluttony - Throat slashed by Ruby with a demon-killing knife.
- Greed - Stabbed in the throat by Ruby with a demon-killing knife.
- Pride - Stabbed in the throat by Ruby with a demon-killing knife.
The Kids Are Alright
- Mr. Doolittle - Tripped and fell on a power saw turned on by a changeling.
- Changeling mother - Burned to death by Sam with a flamethrower, which in turn destroyed the other changelings.
Bad Day at Black Rock
- Wayne - Received bad luck from losing the rabbit foot; slipped on a bottle and fell on a barbecue fork.
- Andy - Shot himself in the neck.
- John - Shot by Reggie for sleeping with his wife.
- Richie - Neck snapped by Casey.
- Father Gil - Shot by Sam with the Colt. His human host was also killed.
- Casey - Shot by Sam with the Colt. Her human host was also killed.
- Jack - Dragged away by a man, who was turned into the Big Bad Wolf by Callie's spirit as part of the Three Little Pigs fairy tale, and viciously killed. The injuries are not shown but the blood was.
- Emmett - Killed by the man Callie's spirit turned into the Big Bad Wolf.
- Ken - Slashed, then stabbed multiple times by the old woman turned into the witch from Hansel and Gretel by Callie's spirit.
- Old woman - Shoved by Julie while carving up Ken, and cracked her skull on a stove.
- Callie Garrison - Went into a coma when her stepmother poisoned her with bleach, and in this state her spirit acted out fairy tales, and finally disappeared at the time of death.
- Crossroads Demon - Shot by Sam with the Colt.
Red Sky at Morning
- Sheila Case - Strangled by the Ghost Ship spirit while in the shower, causing her to die of drowning.
- Peter Warren's brother - Strangled by the Ghost Ship spirit, drowning him.
- Peter Warren - Strangled by the Ghost Ship spirit, drowning him.
- Ghost Ship spirit - Destroyed by the spirit of his brother, whom Sam and Dean summoned.
- Lucy - Decapitated by Dean, as there was no alternative and she was a vampire who killed people.
- Dixon - Presumably decapitated by Dean, though this is never shown nor mentioned.
- Kubrick - Heart pulled out by Gordon. Gordon had been turned into a vampire and wanted to kill Sam, intending to be killed afterward, but Kubrick wanted to kill him right away.
- Vampire - Shot by Dean with the Colt.
- Gordon Walker - Decapitated by Sam when he strangled him with razor wire.
A Very Supernatural Christmas
- Mr. Walsh - Pulled up the chimney and killed by either Madge, Edward, or both.
- Man - Pulled up a chimney and killed by Madge and/or Edward.
- Madge Carrigan - Stabbed by Sam with a stake from an evergreen tree (the only way to kill these two pagan gods).
- Edward Carrigan - Stabbed by Dean twice with a stake from an evergreen tree.
- Janet Dutton - Killed by Amanda with a hex bag, which made her teeth fall out. She was found dead by her husband, Paul.
- Amanda Burns - Killed by the Astaroth with a hex bag. Deep slashes appeared in her arms from her wrist down to her elbow, replicating a suicide.
- Renee - Neck snapped by Astaroth using psychic power.
- Elizabeth - Heart stopped by Astaroth using psychic power.
- Astaroth/Tammi - Stabbed in the back repeatedly by Dean with the demon-killing knife.
Dream a Little Dream of Me
- Doctor - Is said to be killed in his dream by Jeremy, who was using dream root to invade people's nightmares and kill them.
- Jeremy Frost - In his dream, was beaten to death by Sam with a baseball bat, as Sam had also taken dream root and could use the power of the dream world.
- Dean Winchester - Shot by the owner of the Mystery Spot. This was the first of many of Dean's deaths in a time loop created by Gabriel, who set time to rewind each time Dean was killed.
- Dean Winchester - Hit by Mr. Pickett with a car. Was rewound due to the time loop.
- Dean Winchester - Crushed by a falling desk that furniture people were trying to move above him. Was rewound due to the time loop.
- Dean Winchester - Choked on sausages. Was rewound by the time loop.
- Dean Winchester - Slipped in the shower. Was rewound by the time loop.
- Dean Winchester - Poisoned by tacos. Was rewound by the time loop.
- Dean Winchester - Electrocuted while trying to plug in his razor. Was rewound by the time loop.
- Dean Winchester - Accidentally killed by Sam with an axe. Was rewound by the time loop.
- Dean Winchester - Is mentioned to be accidentally shot by Doris with an arrow. Was rewound by the time loop. (Note: According to Sam, the time loop took place many more times than just this, and Dean is killed at the end of each one before it rewinds again)
- Dean Winchester - Mauled to death by a golden retriever. Was rewound by the time loop.
- Dean Winchester - Shot by Cal. Gabriel intended this to be Dean's final death and stopped the time loop, but Sam convinced him to rewind to the beginning of that Wednesday before Dean was shot, ending the time loop for good.
Jus in Bello
- Agent Steven Groves - Possessed by a demon, and when the demon left him he died for unknown reasons.
- Sheriff Melvin Dodd - Shot by a demon, who was possessing Henriksen.
- Demons - Ruby mentions killing several demons.
- Special Agent Victor Henriksen - Killed by Lilith in a flash of white light that caused an explosion. Although when his spirit was later summoned by Lilith and turned evil among others, he claimed their deaths were slower and more vicious
- Agent Calvin Reidy - Killed by Lilith in an explosion of white light.
- Nancy Groves - Killed by Lilith in an explosion of white light.
- Deputy Phil Amici - Killed by Lilith in an explosion of white light.
- Alan J. Corbett - Stabbed through the neck by Daggett's spirit with a spike. His spirit was forced to relive this as a death echo until released by Ed, whom he was in love with.
- Freeman Daggett spirit - Destroyed by Corbett's spirit.
- Corbett's spirit - Destroyed himself and Daggett's spirit to go on to the next world.
Long Distance Call
- Ben - Shot himself in the neck after being convinced to do so by a Crocotta named Clark, imitating Linda.
- Stewie Myers - Soul sucked out of his mouth by Clark, the Crocotta.
- Clark Adams/Crocotta - Back of his head impaled on a metal spike by Sam.
Time is on My Side
- Man - Liver cut out offscreen by Doc Benton, and when someone made him remove his hands from the injury at the hospital, his organs fell out. Benton harvests people's organs to stay immortal.
- Man - Heart cut out by Doc Benton.
- Doc Benton - While he is currently immortal, able to survive any type of injury and able to live forever for as long as he harvests organs, he was chained in a refrigerator and buried by Sam and Dean. It is likely that he will eventually die through his inability to harvest other people's organs and therefore stay immortal while trapped in there.
- Bela Talbot - Killed offscreen by Hellhounds, as she made a deal with a demon ten years ago, and went to hell.
No Rest for the Wicked
- Freckles - Is said to be killed by Lilith. It is unknown what type of animal Freckles was, as he was never seen, but presumably a dog.
- Babysitter - Is said to have been killed by Lilith.
- Demon possessing a cop - Stabbed in the throat by Dean with the demon-killing knife.
- Pat Fremont - Neck snapped by Lilith.
- Dean Winchester - Killed by hellhounds summoned by Lilith due to the deal he made a year ago, and went to hell. Was resurrected by Castiel at the beginning of Season 4.
Are You There, God? It's Me, Dean Winchester
- Olivia - Killed offscreen by the ghost of someone she couldn't save, as Lilith raised ghosts like these (as "the Witnesses") and turned them evil as part of breaking one of the seals. He was shown strangling her, but when her body was seen, there was a lot of blood.
- Jed - Chest ripped out offscreen by one of the Witnesses (spirits of people hunters couldn't save).
- Carl Bates - Is mentioned to have been viciously killed by one of the Witnesses.
- R.C. Adams - Is mentioned to have been viciously killed by one of the Witnesses.
In the Beginning
- Tom - In the past, years before the first episode, was killed by Azazel in a deal made by his son, in exchange for permission to bleed into his kid's mouth in ten years.
- Samuel Campbell - Set years before the first episode, was possessed by Azazel, who stabbed himself, killing Samuel but not really affecting Azazel at all. Was later resurrected by Crowley.
- Deanna Campbell - Neck snapped by Azazel, set before the first episode.
- John Winchester - Neck snapped by Azazel, set before the first episode. Azazel resurrected him afterward in a deal with Mary, setting up his bleeding into Sam's mouth and Mary's subsequent death in the first episode.
- Travis - Neck eaten by Jack, who was turning into a Rugaru, and by doing so completed the transformation and ate Travis's body.
- Jack Montgomery - Incinerated by Sam with a flamethrower, as his transformation into a Rugaru was now irreversible and he was trying to kill Dean
- Marissa Wright - Bitten on the neck offscreen by a shapeshifter, in the form of Dracula
- Rick Deacon - Maimed to death offscreen by a shapeshifter, in the form of a werewolf
- Guard - Strangled by the shapeshifter in the form of a mummy
- Dracula/Lucy/Shapeshifter - Shot by Jamie with Sam's gun loaded with silver bullets, while in Dracula form.
- Frank O'Brien - Died of a heart attack caused by Luther's spirit with Ghost Sickness
- Sheriff Al Britton - Died of a heart attack caused by Luther's spirit with Ghost Sickness
- Luther Garland spirit - Chained to the Impala by Sam and pulled across the road by Bobby, as he is the type of ghost who can be destroyed by fear
It's the Great Pumpkin, Sam Winchester
- Luke Wallace - Killed by Don and Tracy with a hex bag, causing razor blades to appear in his throat. This was part of a sacrifice to break one of the 66 seals, and Don and Tracy are witches who work for Lilith.
- Jenny - Drowned by Don and Tracy in the bobbing apple tub using a hex bag, as part of a sacrifice to break one of the 66 seals.
- Don Harding - Shot in the back by Sam. He was intending to use Tracy as the final sacrifice to awaken Samhain and break one of the 66 seals, but with this Tracy used him as the final sacrifice instead.
- Tracy Davis - Neck snapped by Samhain.
- Justin - Dragged into the crypt and killed by Samhain. Injuries were not shown but blood was.
- Sam Winchester - Struck by lightning because Hope wished for it with the wishing well. When Wes removed the magic coin and broke the spell, the wishes were all reversed and Sam came back to life.
I Know What You Did Last Summer
- Rich Milton - Killed offscreen by Alastair.
- Amy Milton - Killed offscreen by Alastair.
Heaven and Hell
- Alastair's host - Disintegrated when Anna regained her grace and disappeared in an explosion of light. Alastair survived, however, but was thought to be dead until Sam and Dean saw him again.
- Bill Gibson - Killed by the girl in the wall. The injuries she inflicted were not shown, but blood was shown splattering the wall.
- Buster - Killed offscreen by the girl in the wall.
- Ted Carter - Stabbed by the girl in the wall.
- Girl in the wall's brother - Shot by Dean.
- Girl in the wall - Stabbed offscreen by Brian. The sounds of this could be heard.
Criss Angel is a Douche Bag
- Patrick Vance - Killed when Jay, attempting suicide, did the Table of Death magic trick, which skewered him with spikes, but Charlie used a tarot card to transfer the effects to Patrick, killing him instead of Jay.
- Jeb Dexter - Hung on a noose from a ceiling fan, which was transferred from Jay's Executioner magic trick (which would have hanged him) to Jeb by Charlie with a tarot card.
- Charlie the magician - Killed when Jay stabbed himself, leaving a tarot card with Charlie to transfer the stab wound to him.
After School Special
- Taylor - Drowned in a toilet by April, who was possessed by the spirit of Dirk.
- Boy - Hand shoved into a running food processor by another boy, possessed by Dirk's spirit. It seems the victim was a bully and the possessed one was a nerd.
- Barry Cook - Is said to have committed suicide by slitting his wrists, long before the events of the first episode.
- Dirk McGregor - Before events of the first episode, is said to have taken too much drugs, resulting in his death.
- Dirk McGregor spirit - Destroyed when Dean burned a lock of his hair, which was all that remained of him.
Sex and Violence
- Vicki - Killed by Adam with a meat tenderizer. He was under the Siren's influence. (Note: This is not the same Adam that is Sam and Dean's brother)
- Mrs. Bristol - Killed by her son, Lenny, offscreen, under the Siren's influence. Though offscreen, the sounds of it could be heard.
- Nick Monroe/Siren - Stabbed by Bobby with a bronze knife dipped in Dean's blood (as Dean was infected by the Siren, which could only be killed by a bronze knife dipped in the blood of one of its victims).
Death Takes a Holiday
- Cole Griffith - Is said to have died of an asthma attack due to the cold. Returned as a spirit, though not an angry one, and later went on to the next world.
- Reaper - Neck slashed by Alastair with Death's scythe as a sacrifice to break another seal. This seal was saved, though, as he did not get to kill Tessa.
- Pamela Barnes - Stabbed by a demon.
On the Head of a Pin
- Alastair - Killed by Sam using his power, which was now great enough to kill demons.
- Uriel - Stabbed by Anna with an angel-killing sword.
It's a Terrible Life
- Paul - Put his head in a microwave and turned it on (sticking a plastic fork in the latch of the door so the microwave would think the door was closed). His head exploded. He did this under the influence of Sandover's spirit.
- Ian - Under the influence of Sandover's spirit, he stabbed himself in the neck with a pencil.
- Guard - Decapitated when the elevator jerked down, with his head leaning into the elevator door.
- P.T. Sandover's spirit - Was destroyed when Sam burned his gloves with a lighter.
Jump the Shark
- Kate Milligan - Killed offscreen by a ghoul. Her body is found.
- Joe Barton - Killed offscreen by a ghoul. His body is found.
- Adam Milligan - Killed offscreen by a ghoul sometime before the events of the episode in which the ghoul impersonating him appeared. His body is found, and he is later resurrected by angels on Zachariah's orders.
- Kate Ghoul) - Shot in the head by Dean.
- Adam (Ghoul) - Head beaten in by Dean with a crowbar.
- Roger - Possessed by a demon. While possessed his head was smashed in by Jimmy and his throat was slit by Dean.
- Cindy McLellan - Killed offscreen by Ruby, along with the demon possessing her, so that Sam could drink her blood.
- Lilith's demon chef - Killed offscreen by Ruby when she killed Cindy.
- Lilith - Killed by Sam using his power. Unbeknownst to Sam, this was the 66th seal to awaken Lucifer. She was later revived by God.
- Ruby - Stabbed by Dean with the demon-killing knife, while being held in place by Sam.
Sympathy for the Devil
- Castiel - Is said to have been killed by Raphael. However by the end of the episode he is resurrected by God.
- Jimmy Novak - Killed by Raphael along with Castiel. (Later revealed that when Castiel was resurrected the spirit of Jimmy was gone and sent to Heaven)
- Demon - Stabbed by Bobby, who was possessed but was able to stab himself with the demon-killing knife. The demon was killed but Bobby survived.
Good God, Y'All
- Teen 1 - Stabbed by Sam with a demon-killing knife. Sam thought he was a demon due to illusions created by War.
- Teen 2 - Stabbed in the throat by Sam with the demon-killing knife. War's illusions made Sam think he was a demon.
- Pastor - Shot by one of the people who thought he was a demon due to War's illusions.
- Cal - Killed in a car crash caused by Leshii, disguised as James Dean.
- Mr. Hill - Killed by Leshii, disguised as Abraham Lincoln
- Leshii - Decapitated by Sam with an iron axe. Was in Paris Hilton form at the time.
I Believe the Children Are Our Future
- Amber - Killed by itching powder, which was used as a joke by Jimmy, but because Jesse believed it would make people scratch their brains out, that is exactly what it made Amber do
- Man - Electrocuted by Stanley with a Joy Buzzer, since Jesse believed it was powerful enough to kill
The Curious Case of Dean Winchester
- Mr. Xavier - Died of old age, as he lost a Poker game to Patrick in which he bet years of his life.
- Lia - Lost a Poker game to Patrick, and died of old age when she lost all her years. Currently she was 900 years old and outlived her daughter, and was unable to go on because of this.
- Bill Randolph - Killed by the Incredible Hulk, as a trick by the Gabriel. Never seen, but mentioned.
The Real Ghostbusters
- Leticia Gore's spirit - Destroyed when Sam and Dean dug up her grave and burned her bones.
- French man dressed as Hookman - Scalped by the spirits of the three evil kids.
- Evil kids spirits - All three were destroyed when Demian and Barnes dug up their graves and burned the bones.
Abandon All Hope...
- Jo Harvelle - Slashed by a Hellhound. Survived for a few minutes. (Note: She never made a deal, unlike the other victims on this list, as Meg was using Hellhounds as attack dogs, so she did not go to hell)
- Ellen Harvelle - Detonated a bomb to kill the Hellhounds, and was killed in the explosion.
- Meg's Hellhounds - Blown up by Ellen with a bomb.
- Annie - Is said to be killed by a wraith, making it seem a suicide.
- Susan - Blood drained from her brain by a wraith, making it seem a suicide by slitting her wrists.
- Ted - Blood drained from his brain by a wraith, making it seem a suicide by hanging himself.
- Karla the Wraith - Stabbed by Dean with a silver letter opener.
- Maggie Briggs's spirit (poltergeist) - Destroyed when Gary burned her bones.
- Trevor - Impaled by a demon with her hand.
The Song Remains the Same
- Mr. Woodston - Killed offscreen by Anna. His eyes are shown to be burned out.
- Sam Winchester - Stabbed by Anna. Was later resurrected by Michael so he could say yes to Lucifer and fight Michael.
- Anna - Disintegrated by Michael with his power.
My Bloody Valentine
- Russell - Affected by Famine and was eaten by Alice.
- Alice - Affected by Famine and was eaten by Russell.
- Brad - Shot by Janice, who was affected by Famine.
- Janice - Shot in the neck by Jim, who was affected by Famine. So was she.
- Jim - Affected by Famine, he shot himself.
- Lester Finch - Affected by Famine and ate Twinkies until his stomach exploded, even after that he tried to stuff them down his throat. This happened offscreen and was explained by Dr. Corman.
- Dr. Corman - Affected by Famine and drank himself to death.
Dead Men Don't Wear Plaid
- Benny Sutton - Strangled by Clay Thompson, who was raised from the dead, as revenge for killing him.
- Ezra Jones - Stomach eaten by Mrs. Jones, who was raised from the dead by Death and later turned into a zombie.
- Mrs. Jones zombie - Shot in the head by Sam
- Sean Mills zombie - Shot in the head by Sam.
- Karen Singer zombie - Shot in the head by Bobby.
- Clay Thompson zombie - Shot in the head by Dean.
- Several Unknown Zombies - Shot by Sam, Dean, Bobby, and Jody.
Dark Side of the Moon
- Sam Winchester - Shot twice by Walt as revenge for starting the Apocalypse. Was later resurrected by Joshua.
- Dean Winchester - Shot by Walt. Was later resurrected by Joshua.
- Dylan - Pulled under a car and throat slit by a demon.
- Paul - Shot by Jane.
- Leah Gideon - Is mentioned to have been killed by the Whore of Babylon.
- Whore of Babylon - Stabbed by Dean with a stake from a cypress tree. (Note: She can only be killed with this weapon and by a true servant of heaven, and Dean was considered such because he was considering saying yes to Michael)
Point of No Return
- Stuart - Eyes burned out by the presence of Michael.
- Bartender - Eyes burned out by the presence of Michael.
- Zachariah - Stabbed in the throat by Dean with an angel-killing sword.
Hammer of the Gods
- Security Guard - Killed by Mercury so he could be eaten for dinner.
- Man - Decapitated by Zao Shen with a cleaver, presumably so he could be eaten for dinner.
- Zao Shen - Stabbed from behind by Dean with a stake.
- Mercury - Neck snapped by Lucifer with a wave of his fingers.
- Female god - Killed offscreen by Lucifer.
- Brown-haired god - Killed offscreen by Lucifer.
- Dark-haired god - Killed offscreen by Lucifer. His blood was shown splattered on the wall.
- Odin - Stabbed by Lucifer.
- Ganesh - Blown to bloody bits by Lucifer.
- Baron Samedi - Arm torn off and killed in unknown fashion by Lucifer (his blood was shown splattering on the wall).
- Baldur - Impaled by Lucifer with his hand.
- Gabriel - Killed by Lucifer with the angel-killing sword.
The Devil You Know
- Doctor - Killed by another doctor who was infected with Croatoan Virus.
- Mitchell - Throat slit by Brady so he could talk to Pestilence with his blood.
- Brady - Stabbed by Sam with the demon-killing knife, as revenge for Jessica's death.
Two Minutes to Midnight
- Celeste - Killed by several diseases inflicted by Pestilence.
- Doctor - Killed by diseases inflicted by Pestilence.
- Nurse - Killed by diseases inflicted by Pestilence.
- Man - Killed by Death simply by brushing against his shoulder.
- Nick - Decomposed by having Lucifer inside him for too long, as he was not Lucifer's main intended vessel, and fell to the ground dead after Lucifer left him to possess Sam. He was later revived by Crowley to be possessed by Lucifer again.
- Mr. Benson - Killed offscreen by Lucifer, to have fun with Sam as he was one of Azazel's gang.
- Doug - Killed offscreen by Lucifer, to have fun with Sam as he was one of Azazel's gang.
- Rachel - Killed offscreen by Lucifer, to have fun with Sam as he was one of Azazel's gang.
- Castiel - Exploded when Lucifer snapped his fingers, blown to bloody pits. After Lucifer was imprisoned, God resurrected Castiel again.
- Bobby Singer - Neck snapped by Lucifer with a wave of his fingers. Was resurrected by Castiel.
- Though War, Famine, and Pestilence are not strictly killed, they are permenently reduced to a withered state; Sam cuts War's fingers off (including his finger with the ring), and destroys all the demons inside Famine. Pestilence's ring finger is cut off by Castiel. All three disappear from this, and are stated to be "withered husks".
Exile on Main St.
- Sid - Killed by a Djinn
- Sid's wife - Killed by a Djinn
- Djinn 1 - Beaten to death by Sam with a silver golf club.
- Djinn 2 - Stabbed by Samuel with a silver knife.
Two and a Half Men
- Shapeshifter - Shot by Sam with a silver bullet.
- Mark Campbell - Neck snapped by Alpha Shapeshifter.
The Third Man
- Officer Jerry Hatch - Killed by Aaron with the Blood Plague using the Staff of Moses, causing him to turn into blood.
- Officer Toby Gray - Killed by Aaron with the Boil Plague using the Staff of Moses. Boils appeared all over him and inside his throat.
- Officer Ed Colefax - Killed by Aaron with the Locust Plague using the Staff of Moses. Locusts ate away the inside of his head and crawled out of his skull.
- Donnie Finnerman - While possessed by Raphael, was turned to salt by Balthazar with Lot's Salt.
Weekend at Bobby's
- Man - Killed offscreen by a Lamia. Chest was cracked open to drink blood from his heart.
- Demon - Incinerated when Bobby burned her bones from when she was human.
- Priest - Killed offscreen by the Lamia.
- Lamia - Incinerated by Dean with a flamethrower.
- Okami - Ground up in a wood chipper by Bobby.
Live Free or Twihard
- Robert - Decapitated by Dean.
- Boris - Decapitated offscreen by Dean
You Can't Handle the Truth
- Jane - Shot herself in the head due to everyone speaking the truth about her under the influence of Veritas
- Kenny - Killed by Dr. Connelly the dentist with a drill since he spoke a terrible truth to him under the influence of Veritas
- Dr. Paul Connelly - Hung himself in his cell, presumably out of guilt for killing Kenny
- Corey - Is mentioned to commit suicide in a car crash due to receiving the truth about her boyfriend cheating on her
- Mittens - Was killed by Corey to use his/her skull to summon Veritas
- Veritas - Stabbed by Dean and again by Sam with a knife dipped in dog's blood
- Vampire - Decapitated by Gwen
- Guard - Blood sucked by Alpha Vampire
- Christian Campbell - Neck snapped by the Alpha Vampire. However he was possessed by a demon.
All Dogs Go To Heaven
- Ronald Garrigan - Heart torn out by Lucky the Skinwalker.
- Cal Garrigan - Heart torn out by Lucky.
- Skinwalker pack leader - Shot in the head by Sam with a silver bullet.
- Big Skinwalker - Shot by Dean with a silver bullet.
Clap Your Hands If You Believe...
- Fairy - Put in a microwave by Dean, causing it to explode.
- Brennan - Stabbed from behind by Wayne the leprechaun.
- Alpha Shapeshifter - Decapitated by Crowley.
- Demons - The two demons with Sam, Dean, and Meg were killed by Crowley's Hellhounds.
- Hellhounds - Killed by Meg with an angel-killing sword.
- Ghoul - Head bashed by Sam with a metal pole.
- Ghoul - Head stabbed by Sam with a metal pole.
- Christian Campbell (demon) - Stabbed by Dean with the demon-killing knife.
- Brigitta - Killed offscreen by Castiel.
- Presumably every unseen Alpha is killed either by Castiel after Crowley's supposed death, or by Crowley before that (as he killed the Alpha Shapeshifter), or else was somehow killed long ago. It is mentioned by Crowley in Season 7 that the only surviving Alpha is the Alpha Vampire.
Appointment in Samarra
- Robber - Shot in the chest by the clerk he was trying to rob.
- Man - Suffered a heart attack due to eating a pizza with too much cheese.
- Jolene - Killed in a car crash.
- Hilary - Killed by Dean with Death's power, since his refusing to do so when she had a serious heart condition resulted in Jolene's death.
Like a Virgin
- Stan - Burned to death by a dragon offscreen.
- Dragon (not the main one) - Stabbed in the back by Sam with a dragon-killing sword.
- Arachne - Decapitated by Sam. This happened about a year before the events of the episode (sometime after Sam got out of Lucifer's cage).
- Sheriff Roy Dobbs - Turned into an Arachne by the previous Arachne, then decapitated by Sam.
Mannequin 3: The Reckoning
- Steve - Killed by Rose's spirit, possessing a mannequin.
- Dave - Stabbed by Rose's spirit with a metal pole.
- Johnny - Killed offscreen by Rose's spirit.
- Isabel Brown - Killed when Rose's spirit controlled the Impala to attack Sam and Dean, which sent a shard of glass flying into her.
- Rose Brown spirit - Disintegrated in flames as a result of killing Isabel, presumably because Isabel had one of Rose's kidneys, which was all that remained of her.
The French Mistake
- Misha Collins - Throat slit by Virgil so he could talk to Raphael.
- Erik Kripke - Shot three times by Virgil with a shotgun.
- Bob Singer - Shot by Virgil with a pistol. (Not to be confused with Bobby Singer)
- Most of the crew of Supernatural in a parallel dimension was shot by Virgil in a similar style to the Terminator.
...And Then There Were None
- Rick's wife - Killed by the Khan Worm, while possessing Rick. Along with the rest of his family, he kills her with a hammer.
- Khan Worm victim - Shot offscreen by the cops, eight times.
- Gwen Campbell - Shot by the Khan Worm, possessing Dean.
- Samuel Campbell - Shot by Sam, who thought he was possessed by the Khan Worm.
- Rufus Turner - Stabbed by the Khan Worm (possessing Bobby) with a knife.
- Khan Worm - Electrocuted by Dean with electrical cords.
My Heart Will Go On
- Man - Through a series of events caused by Atropos (in a similar style to Final Destination) he is decapitated by his closing garage door. He was part of an alternate universe created by Balthazar when he unsank the Titanic, and was erased along with this alternate reality.
- Anne Witting - Through a series of events caused by Atropos, her scarf is caught in a copier and strangles her. She was part of the alternate reality.
- Shawn Russo - Hit by one of his own buses, set up by Atropos. He was part of the alternate reality.
- Elias's wife - Is mentioned to be killed by the deputy in 1861.
- Judge - Burned to death by Elias with his power in 1861.
- Sheriff - Burned to death by Elias in 1861.
- Rachel - Stabbed by Castiel with her own angel-killing sword.
- Deputy - Shot by Elias in 1861 as revenge for killing his wife.
- Elias Finch - Shot by Dean with the Colt in 1861.
- Ed Bright - Among others, Eve turned him into a monster, but he doesn't turn out exactly right, which kills him.
- Lenore - Smoted by Castiel, at her request.
- Marshall Todd - Among others, Eve tries to turn him into a monster, but doesn't turn out exactly right.
- Ryan and Joe's uncle - Killed by Ryan and Joe, who were turned into Jefferson Starships. Injuries were not shown but his blood was shown splattering on the wall.
- Eve - Bit Dean in the neck when he had phoenix ash in his blood due to drinking it with a shot of whiskey. Phoenix ash is Eve's only weakness, and this kills her.
- Ryan (Alpha Jefferson Starship) - Killed offscreen by Crowley.
- Joe - Killed offscreen by Crowley.
The Man Who Would Be King
- Redd - Presumably killed by Sam or Dean with the demon-killing knife
- Ellsworth - Smoted by Castiel
Let It Bleed
- H.P. Lovecraft - Killed by Dr. Visyak, his blood shown splattering on wall
The Man Who Knew Too Much
- Eleanor Visyak - Mortally wounded offscreen by Crowley and/or Castiel in order to get her blood for the ritual; died onscreen.
- Robin - Shot by Sam to take away a demon's leverage as the demon was holding her hostage. (Took place before first episode of the season, and Sam was soulless at the time)
- Balthazar - Stabbed by Castiel with an angel-killing sword.
- Raphael - Exploded when Castiel snapped his fingers, powered up from absorbing the souls of Purgatory.
Meet the New Boss
- Castiel - Exploded in water releasing the Leviathans into the water supply. (True main antagonist of season 6) Resurrected again.
Hello, Cruel World
- Dr. Gaines (human) - Killed by a Leviathan who then assumed his identity.
- Woman - Eaten by Dr. Gaines the Leviathan.
The Girl Next Door
- Man - Stabbed in the head by Amy with her claws.
- Amy's mother - Stabbed in the heart by Amy to prevent her from killing and eating Sam. This occurred before the first episode.
- Amy - Stabbed in the heart by Dean, who was sure she would continue to kill people even though she only did so to feed her son when he was sick. Dean seemed to feel a bit of regret for this and Sam was angry for a while when he found out.
Defending Your Life
- Matthew Hammond - Killed by the spirit of his victim ramming him with a car, sent after him by Osiris.
- Christopher Fisher - Mauled to death by the spirit of a dog he killed, under the control of Osiris.
- Warren - Shot by the spirit of one of his victims, under the control of Osiris.
- Osiris - Stabbed in the back by Sam with a ram's horn. This is only a temporary death for Osiris, but he'll stay dead for a few centuries, at the least.
Shut Up, Dr. Phil
- Store owner - Boiling cheese poured on him by Chet (who is a Leviathan), then eaten.
- Wendy Goodson - Head burned by Maggie Stark putting a hex on a hairdryer.
- Carl Dunlop - Boiled inside a hot tub offscreen by Maggie.
- Dewey Stevens - Shot by Maggie with a nail gun, which she put a hex on.
- Sue - Decapitated by Don Stark with a plate.
- Megan - Shot by the Leviathans impersonating Sam and Dean.
- Several innocents were shot by Leviathan Sam and Leviathan Dean.
- Deputy - Eaten by Leviathan Sam.
- Sheriff - Eaten by Agent Valente, who is also a Leviathan.
- Coroner - Eaten by Agent Valente.
- Grandma Goly - Stabbed in the throat by Margaret's ghost.
- Nikolai - Impaled on cutlery by Margaret's ghost.
- Kate Fox spirit - Destroyed when Sam burned her bones.
- Camille Thibodeaux - Bones crushed by Margaret's ghost.
- Jimmy Tomorrow - Shot by Sam.
- Margaret Fox spirit - Destroyed when Sam burned her bones.
Season Seven, Time for a Wedding!
- Man - Hit in the face by Jackson with a baseball. He was one of many victims.
- Jackson - Stabbed by Becky with the demon-killing knife
How to Win Friends and Influence Monsters
- Man - Eaten alive by Gerald Browder, under the influence of the Leviathans' drug
- Phil - Eaten by Gerald Browder
- Ranger Rick Evans - Eaten by Gerald Browder
- Gerald Browder - Infected by the Leviathans' drug, then shot multiple times by Sam, Dean, and Bobby
- Dr. Gaines (Leviathan) - Bibbed by Dick Roman. (Dick has a bib put on Dr. Gaines which forces him to eat himself)
- Ed Singer - Shot by Bobby. This occurred before the first episode.
- Bobby Singer- Shot in the head by Dick Roman.
Adventures in Babysitting
- Matthew Havlena - Blood drained offscreen by Sally and Marlene.
- Sally - Stabbed by Krissy with a silver knife.
- Marlene - Stabbed by Sam with a silver knife.
Time after Time
- Man - Energy drained by Kronos, ageing him
- Kronos - Stabbed in the heart by Sam with a stake dipped in blood. (What kind of blood is unknown)
The Slice Girls
- Man - Hands and feet cut off by an Amazon
- Jerry Price - Hands and feet cut off by an Amazon
- Charlene Penn - Shot by Sam
- Emma - Shot by Sam
Plucky Pennywhistle's Magical Menagerie
- Mr. Harper - Blood sucked by an "octovamp" (half octopus half vampire) conjured by Howard
- Mr. Pogue - Impaled by the horn of a unicorn conjured by Howard
- Saul - Bitten by a shark in a ball pool conjured by Howard
- Howard - Drowned due to Dean throwing a picture of his brother drowning and one of his possessions into his magic fire. The apparition of his brother caused him to drown with a simple touch.
- Jeffrey - Shot multiple times by Dean.
Out with the Old
- Irina - Danced her feet off due to cursed shoes
- Woman - Drank boiling hot tea from a cursed kettle
- Mr. Marshall - Neck snapped by Joyce (who is a Leviathan)
- Frank Devereaux - Killed offscreen by Leviathans
The Born-Again Identity
- Marin's brother's spirit - Destroyed when Sam burned her bracelet, which has his blood on it.
Party On, Garth
- Trevor McAnn - Killed by the shojo
- Ray McAnn - Killed by the shojo
- Lillian - Killed by the shojo
- Shojo - Stabbed by Dean with a sword
Of Grave Importance
- Teenage boy and girl - Killed by Whitman's ghost
- Annie - Killed by Whitman's ghost
- 2 teens - Killed by Whitman's ghost
- Dexter O'Connell ghost - Destroyed by Whitman's ghost as punishment for trying to warn people off
- Victoria ghost - Destroyed by Whitman's ghost
- Whitman Van Ness ghost - Destroyed when Dean burned his bones
- All the ghosts in the mansion, including Annie and Crane, were destroyed when Sam and Dean burned their bones, so they could rest in peace
The Girl with the Dungeons and Dragons Tattoo
- Pete - Eaten by Tarrell, who then assumed his identity
- Victor - Eaten by Dick Roman
Reading is Fundamental
- Rosco - Stabbed by Meg with a demon-killing knife
- Hester - Stabbed in the back by Meg with an angel-killing sword. This is the only instance of a demon killing an angel.
Survival of the Fittest
- Polly - Injected by Dick Roman with an additive.
- Bobby Singer (ghost) - Put to rest by Dean burning his flask because he was going vengeful. Afterwards Crowley had a rogue Reaper take him to hell, but Sam later got him into Heaven.
- Dick Roman - Stabbed in the neck by Dean with the bone of a righteous mortal dipped in the blood of the three fallen, fallen angel, father of fallen beast and the ruler of fallen humanity ( Castiel, Alpha Vampire and Crowley respectively with the bone of Sister Mary Constant).
We Need To Talk About Kevin
- Channing's roommate - Throat slashed by demon possessed Channing in order to communicate with Crowley.
- Channing - Neck telekinetically snapped by Crowley, who was enraged that Kevin escaped again.
What's Up, Tiger Mommy?
- Demon possessing Mrs. Tran's neighbor - Forced back into meatsuit with a reverse exorcism and stabbed with demon-killing knife.
- Ruguru - Tortured for information on Castiel's location in Purgatory, stabbed through bottom of its mouth with demon-killing knife.
- Plutus - Wooden stake shoved into back by Beau after its revealed Beau made a deal with Crowley to get him into the auction with some of his powers intact.
- Plutus's henchman - Stake thrown into chest by Crowley.
- Beau - Smashed to by Sam with Thor's Hammer.
- Mr. Vili - Destroyed by Thor's Hammer after Sam remembers that Mr. Vili would have had to kill a virgin to have 5/8 of one to pay for the hammer with.
- Unknown victim - Heart ripped out by Paul Hayes as an offering to Cacao due to a spell that was indwelt into the kidney he received from a transplant (Mentioned, took place 6 months prior)
- Unknown jogger - Heart ripped out by Paul Hayes as an offering to Cacao.
- Pizza delivery man - Heart ripped out by Arthur Swenson as an offering to Cacao due to spell that was indwelt into an eye he received from a transplant (Mentioned)
- Unknown victim - Heart ripped out by Arthur Swenson as an offering to Cacao (Mentioned, took place 6 months earlier)
- Brick Holmes - Kills himself in car crash in order to end his sacrifices to Cacao, organs donated to 6 known people.
- Strip club patron - Heart ripped out by Randa Moreno as an offering to Cacao due to spell indwelt into heart she received from transplant.
- Randa Moreno - Stabbed in heart by Dean ending the spell on it and the other organs donated from Brick Holmes's body.
- Paul Hayes - Dies as a result from the spell on his kidney being broken.
- Jimmy Tong - Dies as a result from the spell on his transplanted organ being broken
- Murder victim - Killed with heart eaten by Professor Ludensky, having fallen off the wagon of only eating animal hearts.
- Professor Ludensky - Shot in the heart with a silver bullet by Dean.
- Scott - Killed with heart eaten by Michael Wheeler, after Professor Ludensky turned Micheal into a werewolf to use as a scapegoat. (Mentioned)
- Michael Wheeler - Stabbed in the heart with a silver letter opener by Brian Wilcox, out of jealousy of Michael's relationship with Kate.
- Brian Wilcox - Torn apart by Kate after being turned by him. Revenge for Brian killing Michael.
- Quentin - Beheaded by Benny as revenge for holding him down to be killed.
- Sorento - Beheaded by Benny
- Benny's Maker - Beheaded by Benny
- Andrea - Beheaded by Dean
- Chester Lew - Crushed by car after his ghost possessed wife lowers the car jack as he's working on the car, then ran over.
- Jeff - Killed with a shovel by Scott Lew, possessed by Vance.
- Sherriff - Shot with shotgun by Deputy Doug, possessed by Vance
- Vance Collins spectre - Destroyed after his penny is destroyed by Garth
A Little Slice of Kevin
- Krista - Made to explode by a snap of Crowley's fingers
- Demon in car trunk - Stabbed with demon-killing knife
- Gary Freleng - Heart beats out of chest in a Looney Toon's sort of way
- Unknown man - Attempting suicide he sees he's able to walk on air until he looks down causing him to fall.
- Security Guard - Crushed by a 1 ton anvil
- Dr. Dwight Mahoney - Forced to shoot himself in the head by Fred Jones in order for Dr. Mahoney to never hurt anyone ever again.
- Customer from diner - Neck ripped out and blood drained by Desmond
- Unknown victim - Drained by Desmond
- Desmond - Beheaded by Benny, saving Dean's life
- Martin Creaser - Neck ripped out by Benny for endangering his great grand daughter Elizabeth's life
Torn and Frayed
- Viggo - Stabbed by Dean with demon-killing knife
- Samandriel - Stabbed in the heart with angel sword by Castiel on Naomi's orders
LARP and the Real Girl
- Ed Nelson - Drawn and quartered by unseen force, later revealed to be Gilda acting on orders from Gerry.
- Lance Jacobsen - Belladonna poisoning, seen coughing and vomiting blood and bleeding from eyes, later revealed to be Gilda under Gerry's orders
As Time Goes By
- Men of Letters members - Slaughtered by Abaddon in various ways
- Hotel manager - Throat slashed by Abaddon after she finished reading his memories.
- Comic store clerk - Killed by Abaddon (Unseen)
- Larry Ganem - Stabbed by Abaddon, who unknowingly possessed his wife.
- Henry Winchester - Abaddon impales him through the stomach with her hand, dies from wound.
Everybody Hates Hitler
- Nazi Soldiers - Variously slaughtered by Golem
- Rabbi Isaac Bass - Magically burned alive by Torvald
- Torvald - Neck snapped by Golem, body burned to prevent resurrection
- Commander Eckhart - Shot in the head by Sam and Dean, and body burnt to prevent resurrection.
Trial and Error
- Carl Granville - Ripped apart by hell hound, 10 year crossroads deal was up (Made deal for wife to fall in love with him)
- Margot Cassity - Ripped apart by hell hound, 10 year crossroads deal was up (Made deal for families wealth)
- Juliet (Hellhound) - Disemboweled with demon-killing knife by Sam who lets the blood pour over himself completing the first Demon Tablet trial.
Man's Best Friend with Benefits
- Hooker - Murdered by Spencer, evidence planted to frame James Frampton out of jealousy over Portia
- Blind man - Murdered by Spencer, second frame job on James
- Phillippe LeChat - Neck telekinetically snapped by Spencer for revealing the truth to Sam and Dean.
- Spencer - Vaporized with a witch bomb.
Remember the Titans
- Shane aka Prometheus - Hit by a drunk driver who totally passed out in the middle of driving (Resurrects)
- Shane - Mauled by bear (Resurrects)
- Shane - Heart attack caused by fight with Artemis (Resurrects)
- Oliver - Dies from a fall (Being Prometheus's son causes him to resurrect)
- Oliver - Murdered by Zeus to torture Shane aka Prometheus (Resurrects)
- Shane/Prometheus - Used as shield by Zeus to protect himself from an arrow Artemis shoots at him. (Permanently due to Zeus's death)
- Zeus - Prometheus shoves the arrow through his own chest into Zeus's in order to end the curse on both him and his son.
- Test Dean - Stabbed through chest with angel sword by Castiel (Test of loyalty given by Naomi)
- Warehouse full of Test Deans - Killed off screen by Castiel
- Ann Morton - Found dead by husband, either stabbed with the angel sword or smote (Possessed)
- Wendy Rice - Stabbed in the chest with angel sword by Castiel on orders from Naomi (Possessed)
- Meg - Stabbed in the chest with angel sword by Crowley (Second main antagonist of Season 1)
Freaks and Geeks
- Vampire - Beheaded by Aiden, the vampire that Victor Rogers said Aiden's family was killed by.
- Jimmy Day - Beheaded by Josephine, Victor told her that Jimmy killed her family
- Seth - Shot in the eye with dart filled with dead man's blood by Krissy, vampire that was actually responsible for all the family member murders
- Victor Rogers - Commits suicide when everyone leaves him for being the mastermind behind the murders of their families.
- Crossroad Demon - Mercy killed by Dean to escape Crowley's wrath, as Deans end of the deal for giving Dean information for an entrance into hell
- Ajay - Impaled with angel sword by Crowley for helping Sam get into hell.
- Benny Lafitte - Beheaded by Dean so he could lead Sam to God's human Purgatory escape portal, decides to stay in Purgatory.
- Jennifer O'Brien - Stabbed with a silver knife dipped in lamb's blood by Sam and Dean. Covered up the deaths caused by her son.
- Jennifer O'Brien's son - Stabbed with a silver knife dipped in lamb's blood by Sam. The djinn responsible for the deaths
- Gertrude Middleton - Presumably taken off life support after Charlie reads her The Hobbit one last time. (She was in this position from being hit by drunk driver Russell Wellington)
The Great Escapist
- Kara - Eyes burnt out left alive to tell Castiel that he has to stop hiding, neck telekinetically snapped by Naomi
- Esper - Shot in the neck with a bullet made from angel sword.
- Ion - After removing the angel sword bullet from his own body Castiel shoves it through Ion's eye
- Tommy Collins - Head explosion caused by Crowley as retaliation for Sam going through with the Demon Tablet trials (Season 1 Wendigo victim/ survivor)
- Old woman - Died as a result of the brutal exorcism performed to get a demon to leave her body.
- Jenny Klein - Burnt in her oven due to Crowley planting a hex bag in her apartment. (Season 7 witch victim/ survivor)
- Jane the waitress - Stabbed in the back by Castiel with an angel sword, first Angel Tablet "trial" (Nephilim)
- Sarah Blake - Died as a result of a hex bag Crowley planted (Season 1 ghost victim / survivor)
I Think I'm Gonna Like It Here
- Hael - Stabbed by Castiel with an angel blade
Devil May Care
- Pete - Hanged by Abaddon
- Irv - Shot by a demon sailor with a sniper rifle
- Jason - Killed offscreen by Gadreel with the demon-killing knife
I'm No Angel
- Maurice - Stabbed in the throat by Dean with an angel blade
- Castiel - Stabbed by April. He was revived by Gadreel
- April - Stabbed by Dean with an angel blade
- Peter Jenkins - Stabbed by Haggerty with his own knife. (Set in the past)
- Charlie Bradbury - Killed by the Wicked Witch of the East with an energy ball meant for Dean, whom she jumped in front of. She was revived by Gadreel
- Wicked Witch of the West - Stabbed in the head by Charlie with the Ruby Slippers.
Dog Dean Afternoon
- Max Alexander - Broken in half by Chef Leo
- Receptionist - Killed by Chef Leo in a "gory discretion shot" style
- Chef Leo - Mauled to death by dogs
Heaven Can't Wait
- Joe - Exploded into pink goo by Ephraim
- Teenage girl - Exploded into pink goo by Ephraim
- Ephraim - Stabbed by Castiel with an angel blade
- Jack - Impaled by a tractor controlled by Timmy's mother's ghost
- Ruth - Drowned in her own bath by Timmy's mother's ghost
Rock and a Hard Place
- Pastor Fred - Killed offscreen by Vesta
- Vesta - Stabbed in the back by Jody with an oak stake dipped in virgin's blood
- Bartholomew's handmaiden - Stabbed by Malachi with an angel blade
- Muriel - Stabbed by Theo with an angel blade
- Azrael - Is mentioned to be killed in the fall when Metatron cast his spell to banish the angels from Heaven
- Sophia - Is mentioned to be killed in the fall when Metatron banished the angels from Heaven
- Ezekiel - Is mentioned to be killed in the fall when Metatron banished the angels from Heaven
- Theo - Smote by Castiel
- Kevin Tran - Smote by Gadreel
- Thaddeus - Stabbed by Gadreel with an angel blade
- Abner - Throat slit offscreen by Gadreel with an angel blade
- Cecily - Stabbed by Abaddon with an angel blade
- Colette - Neck snapped by Abaddon while she was possessing her. (Set in flashback in 1863)
- Sheriff Pat - Silver knife thrown at him by Dean, stabbing him in the heart
- Russ - Stabbed in the back by Dean with a silver knife
- Joba - Stabbed in the heart by Dean with a silver knife
- Joy Myers - Shot in the heart by Dean with a silver bullet
- Wayne McNut - Killed when Alonzo sucked out all his fat
- Woman - Killed when Alonzo sucked out all her fat
- Larry - Killed offscreen by Alonzo, likely by stabbing him in the neck
- Alonzo - Tongue cut off by Dean with a silver knife
- Rebecca - Killed offscreen by Bartholomew
- Eliah - Stabbed in the heart by Bartholomew with an angel blade
- Bartholomew - Stabbed by Castiel with an angel blade
- Del - Stabbed by Linda with the demon-killing knife
- Casey Miles - Killed offscreen by Roger
- Trey - Throat slit by Roger
- Roger/Thinman - Stabbed by Dean with his own knife
- Deputy Tom Norwood - Shot by Harry
- Lola - Stabbed by Crowley with an angel blade
- Cuthbert Sinclair - Decapitated by Dean with the First Blade
Mother's Little Helper
- Ric Young - Beaten to death by Karen with a candle holder
- Karen Young - Hanged herself offscreen
- Mr. Richie - Stabbed by Sam with the demon-killing knife
- Sister Agnes - Stabbed by Sam with the demon-killing knife
Alex Annie Alexis Ann
- Cody - Decapitated by Jody with a fire axe
- Woman - Blood sucked by Celia
- Dale - Decapitated by Dean
- Connor - Decapitated by Dean with the demon-killing knife
- Celia - Decapitated by Jody
- Tamara - Shoved by Irv, hitting her head against a wall
- Sal Lassiter - Slashed by Irv
- Maurice - Decapitated by Dean
- Irv Sokolowski - Shot by Ennis
King of the Damned
- Malachi - Killed offscreen by Gadreel
- Ezra - Stabbed offscreen by Josiah with an angel blade
- Abaddon - Stabbed by Dean with the First Blade
Stairway to Heaven
- Oren - Blew himself up with an angel suicide bomb (carving a symbol on his chest and stabbing himself)
- Constantine - Blew himself up with an angel suicide bomb
- Tyrus - Killed in Constantine's explosion
- Tessa - Stabbed herself with the First Blade
Do You Believe in Miracles?
- Gadreel - Blew himself up with an angel suicide bomb
- Dean Winchester - Stabbed by Metatron with an angel blade. He was revived as a demon by the Mark of Cain, later turned human again.
- Drew Neely - Stabbed by Dean repeatedly with the First Blade
- Daniel - Stabbed by Castiel with an angel blade (reluctantly, as he was attacking Hannah who was trying to force him to return to Heaven against his will)
- Ed Trenton - As shown in flashback, was killed by Dean with a knife (as he was a monster).
- Lester Morris - Stabbed by Dean
- Adina - Stabbed in the heart by Crowley with an angel blade
- Biker - Throat slashed by Tasha
- Travis - Stabbed in the heart by Sam with a silver knife
- Brandon - Stabbed in the heart by Sam with a silver knife
- Tasha - Stabbed in the heart by Kate with a silver knife
- Calliope - Stabbed by Dean with a blessed wooden stake
- Scarecrow - Destroyed when Dean killed Calliope
- Bunny LaCroix - Died offscreen
- Colette - Pushed off the staircase balcony by Olivia (as Bunny)
- Stanton - Decapitated by Olivia (as Lance)
- Phillip - Stabbed in the back by Olivia offscreen with a knife
- Detective Howard - Drowned in a toilet offscreen by Olivia
- Olivia - Shot multiple times by Dean with silver bullets
Girls, Girls, Girls
- Tiana - Neck snapped by Raul
- Raul - Killed by Rowena with the spell To Bind and Purge
- Elle - Killed by Rowena with the Attack Dog spell
- Howie - Killed offscreen by Star
- Len - Decapitated by Star
- Star - Decapitated by Donna
The Things We Left Behind
- Gerald - Stabbed in the back of the head through the mouth by Crowley with an angel blade
- Salinger - Killed offscreen by Dean
- Randy - Killed offscreen by Dean
The Hunter Games
- Guthrie - Stabbed by Rowena with an angel blade
There's No Place Like Home
- Russell Wellington - Stabbed by Dark Charlie with a letter opener
- Clive Dillon - Shot in the head by Charlie, at his request
- The Wizard of Oz - Killed when Charlie killed Clive, as he is his dark half and they are connected
About a Boy
- JP - Eaten offscreen by Katja
- Hansel - Stabbed by Dean with a kitchen knife
- Katja - Thrown into her oven by Dean
Halt & Catch Fire
- Billy - Killed when Andrew's spirit made the car he was in drive off a bridge
- Julie - Strangled by Andrew's spirit with a power cord
- Kyle - Killed when Andrew's spirit cranked his speakers up high
The Executioner's Song
- Tommy Tolliver - Stabbed by Cain
- Crossroads Demon (The Executioner's Song) - Killed offscreen by two of Crowley's demons
- Cain - Stabbed by Dean with the First Blade
The Things They Carried
- Jackie Prescott - Throat slit by the Parasitic Khan Worms, possessing Rick
- Rick Willis - Set himself on fire with gasoline, possessed by the Parasitic Khan Worms
- Shop worker - Throat slit by the Parasitic Khan Worms, possessing Kit
- Parasitic Khan Worm 1 - Stomped on by Sam
- Parasitic Khan Worm 2 - Stomped on by Dean
- Kit Verson - Shot in the head offscreen by Sam, as he was possessed by a Khan Worm and was about to kill him
- Parasitic Khan Worm 3 - Killed offscreen by Sam
Paint it Black
- Terry Sloan - Possessed by Isabella's spirit to disembowel himself with a candlestick
- Frank McCarthy - Stabbed by Isabella's spirit, possessing Lisa, with a pair of scissors
- Piero - As shown in flashback, stabbed by Isabella with a knife
- Father Delaney - Gutted offscreen by Isabella's spirit
- Isabella spirit - Destroyed when Sam burned the portrait containing her finger and blood
- Angry cupid - Stabbed in the back by Metatron with an angel blade
Book of the Damned
- Jacob Styne - Stabbed by Sam
The Werther Project
- Suzie's father - Shot himself offscreen under the influence of the Werther Box. (Set years before the events of the series)
- Suzie's brother - Hanged himself under the influence of the Werther Box. (Set years before the events of the series)
- Suzie's mother - Slit her throat with a knife under the influence of the Werther Box. (Set years before the events of the series)
- Suzie - Shot herself under the influence of the Werther Box
- Ronnie Cartwright - Stabbed by Tamiel with a Grigori angel blade
- Tamiel - Stabbed in the back by Claire with an angel blade
- Amelia Novak - Stabbed by Tamiel, who was trying to stab Claire but she jumped in front of her. In death she was reunited with Jimmy in Heaven
- Eileen - Throat slit by Eldon
- Office manager - Killed offscreen by Eldon
- Charlie Bradbury - Violently killed offscreen by Eldon
- Bully - Mutilated by Cyrus, which Monroe forced him to do
- Eli Styne - Throat slit by Dean
- Monroe Styne - Neck snapped by Dean
- Roscoe Styne - Stabbed in the back by Dean
- Eldon Styne - Shot in the head by Dean
- Cyrus Styne - Shot in the head by Dean, despite being neither evil nor supernatural
- Rose McKinley - Blood sucked offscreen by Reggie
- Rudy - Stabbed by Reggie
- Reggie - Decapitated by Dean
- Death - Impaled by Dean with his own scythe
- Oskar - Stabbed in the neck by Rowena with a pen as a sacrifice for the spell to remove the Mark of Cain from Dean
Out of the Darkness, Into the Fire
- Janie Schneider - Complications due to childbirth. Gave birth to Amara, the Darkness's vessel, offscreen.
- Mike Schneider - Infected by the rabid virus caused by the Darkness's release, which eventually killed him
- Marnie's husband - Killed offscreen by Crowley
- Dale - Killed offscreen by Crowley
- Debb - Killed offscreen by Crowley
Form and Void
- George - Infected by the Darkness's virus, which eventually killed him
- Jenna's grandmother - Throat slit by Jenna with a kitchen knife, because Jenna's soul was sucked out by Amara
- Jonah - Stabbed by Castiel with an angel blade
- Hannah - Stabbed in the back of the head by Efram with an angel blade
- Efram - Stabbed by Castiel with an angel blade
- Jenna Nickerson - Sent falling from the ceiling by Crowley
The Bad Seed
- Demon Nanny - Eaten by Amara
- Demon Nanny 2 - Eaten offscreen by Amara
- Deputy Donnelly - Penny put in his mouth by Dean (to remind him he's dead), then decapitated with the door of the Impala (the only way to kill a Nachzehrer).
- Girl - Hit in the back by Sidney (whose soul was sucked out by Amara) with an axe.
- Boy - Hit in the back by Sidney with an axe.
- Mrs. Kemper - Killed by Sidney with an axe
- Mr. Pinsky - Killed offscreen by Sidney, presumably with an axe
- Dawn Pinsky - Killed offscreen by Sidney, presumably with an axe
- Sidney - Hit in the back by Len with an axe
Our Little World
- Len Fletcher - Killed offscreen by Marco
- Marco - Stabbed by Dean with the demon-killing knife
- Stan Hinkle - Stabbed by Chester's spirit with a broken bottle
- Mike Hooks - Shot by Doug Stover
- Phil Evans - Throat slit by Chester's spirit with a scalpel
- Chester Johnson spirit - Destroyed when Sam burned his deer mask, after all his other costumes had been burned.
Just My Imagination
- Sparkle - Stabbed by Reese with a knife
- Nicky the mermaid - Stabbed by Reese with a knife
O Brother Where Art Thou?
- Preacher - Struck by Amara with lightning
- Priest - Violently thrown by Amara after sucking out his soul, hitting his head against the pulpit
- Head Angel - Smote by Amara
- Daniel - Forced by Amara to stab himself in the throat with an angel blade
The Devil in the Details
- Ambriel - Eaten by Amara
- Rowena - Neck snapped by Lucifer. She was revived through a resurrection spell she set up earlier
Into the Mystic
- Padraic - Affected by the Banshee and bashed his head against the wall. (Set 30 years ago)
- Padraic's wife - Sacrificed herself to cast a spell to banish the Banshee. (Set 30 years ago)
- Harold Miller - Bashed his head against the wall offscreen, affected by the Banshee.
- Park angel - Destroyed by Lucifer snapping his fingers.
- Arthur - Affected by the Banshee and fell out the window
- Banshee - Stabbed by Eileen with a gold knife
Don't You Forget About Me
- Stephen Phelps - Neck snapped offscreen by Henry
- Richard Beesome - Decapitated by Dean
- Henry - Decapitated by Claire
- Staci Altman - Heart pulled out by the Qareen, disguised as Dan
- Dan Harper - Heart pulled out by the Qareen, disguised as Staci
- Sonja - Shot by Sam with witch-killing bullets
- Qareen - Heart stabbed by Sam with a knife
- Befehlsleiter Gumprecht - Stabbed in the neck and gut by Delphine. Revived due to being part of the Thule Society and his body wasn't burned. (Set in 1943)
- Befehlsleiter Gumprecht - Blown up when Delphine used the Hand of God to blast a hole through his German Destroyer offscreen. (Set in 1943)
- Delphine Seydoux - Destroyed along with the submarine when she used the Hand of God's power to destroy Gumprecht's German Destroyer. (Set in 1943)
- Captain James Dearborn - Destroyed by Delphine with the Hand of God. (Set in 1943)
- Petey Giraldi - Destroyed by Delphine with the Hand of God. (Set in 1943)
- Harris - Destroyed by Delphine with the Hand of God. (Set in 1943)
Beyond the Mat
- Larry "the Hangman" Lee - Hanged by Gunnar, who then collected his soul for Duke, sending him to hell
- Spectator - Stabbed by Gunnar, and went to hell when Gunnar collected his soul for Duke
- Shawn Harley - Slashed offscreen by Gunnar, and went to hell coz Gunnar collected his soul for Duke
- Simmons - Destroyed by Crowley with an energy wave using the Rod of Aaron, intended for Lucifer whom she jumped in front of.
- Duke - Stabbed from behind by Gunnar with the demon-killing knife.
- Gunnar Lawless - Killed offscreen by Hellhounds due to making a deal with Duke, and went to hell.
- Soul Eater - Destroyed when Sam drew a Soul Eater killing sigil in blood, when Dean drew the same symbol in the Soul Eater's realm. (This is the same Soul Eater Bobby and Rufus faced, as Dean runs into Bobby in its nest which is outside of time and space, but not the same one Bobby trapped in his earlier days, which Sam and Dean will kill the same way)
- Werewolf that shot Sam - Stabbed in the back by Dean with a silver knife
- Charlie - Mauled to death offscreen by Rose or the big werewolf
- Dean Winchester - Killed himself with a drug overdose to talk to Billie the reaper. He is revived by Dr. Kessler with a needle.
- Big werewolf - Stabbed by Sam with a silver blade.
- Rose - Killed offscreen by Sam with a silver blade
- Dr. Kessler - Killed offscreen by Corbin, who had become a werewolf after being bitten.
- Sheriff Ben Anderson - Impaled by Corbin with his hand.
- Corbin Tilghman - Shot in the back by Sam with a silver bullet.
- Jofiel - Destroyed by Lucifer snapping his fingers.
- Matty - Possessed by a Bisaan, and eventually died offscreen from the possession. (Set in 1989)
- Cliff - Mauled by a Bisaan (possessing Grant Hollister), who tore a chunk out of his neck.
- Libby - Possessed by a Bisaan
- Grant Hollister - Possessed by a Bisaan
- Bisaan - The males were decapitated by Dean and Cesar, the females died after getting pregnant, and the larva were burned offscreen by Dean
Don't Call Me Shurley
- Art Harris - Killed offscreen by Jan (who was infected by Amara's virus). She was revived by Chuck, who is God
- Deputy Jan Harris - Shot by Sheriff Mac. She was revived by Chuck
- Townspeople - Died due to Amara's fog
- Sam Winchester - Became infected with Amara's fog.
All in the Family
- Metatron - Imploded into nothingness by Amara.
We Happy Few
- Clea - Killed when Amara deflected Rowena's spell back at her when she was connected to her and other witches
Keep Calm and Carry On
- Jervis - Stabbed by Crowley with an angel blade
- Jervis's partner - Stabbed by Crowley with an angel blade
- Ms. Watt - Stabbed in the back by Mary with an angel blade
- Natalia - Heart frozen offscreen by Moriarty's spirit
- Dave - Heart frozen offscreen by Moriarty's spirit
- Hugo Moriarty's spirit - Destroyed when Sam burned his bones
- Olivia Sanchez - Inside of her head liquefied by Magda when she tried to contact her with her power
- Ricky Kopelin - Inside of his head liquefied by Magda when she tried to contact him with her power
- Abraham Peterson - Poisoned by Gail Peterson putting rat poison in his food
- Elijah Peterson - Stabbed by Gail Peterson with a knife, intended for Magda whom he jumped in front of
- Magda Peterson - Shot by Arthur Ketch
The One You've Been Waiting For
- Marvin Brickle - Spontaneously combusted by Nauhaus
- Candy Lloyd - Spontaneously combusted by Nauhaus
- Nick - Spontaneously combusted by Nauhaus
- Fritz - Shot by Christoph. His body was later burned by Sam, Dean, and Ellie to prevent his resurrection
- Hans - Shot in the head by Ellie. His body was later burned by Sam, Dean, and Ellie to prevent his resurrection
- Wolfgang - Shot in the head by Dean. His body was later burned by Sam, Dean, and Ellie to prevent his resurrection
- Gottfried - Shot in the head by Dean. His body was later burned by Sam, Dean, and Ellie to prevent his resurrection
- Adolf Hitler - Shot in the head by Dean. His body was later burned by Sam, Dean, and Ellie to prevent his resurrection
- Nauhaus - Shot in the head by Dean while possessed by Hitler. His body was later burned by Sam, Dean, and Ellie to prevent his resurrection
Celebrating the Life of Asa Fox
- Asa Fox - Shoved by Bucky, accidentally hitting his head on a rock (as shown in flashback). Body was hanged to make it seem like Jael was the killer
- Randy Bull - Throat slit by Jael
- Elvis Katz - Killed when Jael snapped his neck while possessing him
Rock Never Dies
- Gordy - Neck snapped by Lucifer
- Adam - Neck snapped by Lucifer
- Russell - Forced to stab himself in the throat by Lucifer
- Band member played by Scott McNeil - Neck snapped by Lucifer
- Tommy - Neck snapped by Lucifer
- Vince Vincente - Possessed by Lucifer, decaying his vessel, then died when Lucifer left him
- Wallace Parker - Killed offscreen from Lucifer possessing him
- Archbishop - Killed offscreen from Lucifer possessing him
- Jeff's assistant - Killed by Lucifer causing a massive cerebral hemorrhage
- Louis - Exploded by Crowley
- Sam Winchester - Temporarily killed by Billie as part of their deal
- Dean Winchester - Temporarily killed by Billie as part of their deal
- Billie - Stabbed from behind by Castiel with an angel blade
- Agent Camp - Throat slit offscreen by Arthur Ketch
- Rick Sanchez - Throat slit offscreen by Arthur Ketch
Lily Sunder Has Some Regrets
- Benjamin - Stabbed by Lily Sunder with an angel blade
- Mirabel - Stabbed by Lily with an angel blade
- Akabel - Stabbed by Mirabel with an angel blade. (Set over a hundred years in the past)
- May - Killed offscreen by Ishim. (Set over a hundred years in the past)
- Ishim - Stabbed from behind by Castiel with an angel blade.
- Barry Gilman - Killed offscreen by Catriona with a hex bag making money appear in his stomach
- Gideon Loughlin - Shot by Dean with a witch-killing bullet, mortally wounding him.
- Catriona Loughlin - Shot by Dean with a witch-killing bullet
- Boyd Loughlin - Shot by Dean with a witch-killing bullet
Stuck in the Middle (With You)
- Wally - Stabbed by one of Crowley's demons
- Demon that killed Wally - Stabbed from behind by Dean with an angel blade
- Ramiel - Stabbed by Sam with the Lance of Michael, exploding in a puff of smoke as it does to demons
- Teacher - Heart crushed by Fiona's spirit six months before the episode. This was undone when Gavin went back in time
- Scout leader - Heart crushed by Fiona's spirit. This was undone when Gavin went back in time
- Pembroke teacher - Heart crushed by Fiona's spirit. This was undone when Gavin went back in time
- Gavin McLeod - Killed offscreen when the ship he was on sank in a storm after returning to the past, as was his original fate.
- Kris - Presumably decapitated by Dean
- Vampire hostage - Decapitated by Mary
- Alton Morehead - Stabbed in the back by Alpha Vampire with his claws
- Serena Colman - Blood sucked by Alpha Vampire
- Alpha Vampire - Shot in the head by Sam with the Colt
- Pierce Moncrieff - Presumably killed by Arthur Ketch (likely torturing him first)
Somewhere Between Heaven and Hell
- Marcus - Slashed in the back by Ramsey. (As he did not sell his soul, he does not go to hell)
- Victor - Exploded by Lucifer snapping his fingers.
- Thomas - Exploded by Lucifer snapping his fingers.
- Ramsey the Hellhound - Stabbed by Sam with an angel blade.
Ladies Drink Free
- Ben Foster - Heart torn out by Justin
- Hayden Foster - Injected by Mick with silver nitrate, because Justin bit her and she was turning into a werewolf
- Justin - Shot in the back by Mick with a silver bullet
The British Invasion
- Timothy - Stabbed by Mick with a knife. Set in 1987
- Dr. Turner - Slashed by Dermot with a knife.
- Dermot - Killed offscreen by Eileen with an angel blade
- Renny Rawlins - Shot by Eileen with the Colt, intended for Dagon who teleported out of the way
- Mick Davies - Shot in the back of the head by Arthur Ketch
The Memory Remains
- Jared Hayes - Blood drained offscreen by Moloch
- Daryn Boston - Blood drained by Moloch
- Pete - Shot by Sam
- Moloch - Shot by Sam with the Colt
- Kelly Kline - Slit her wrist. She was revived by Jack (the nephilim inside her)
- Kelvin - Destroyed offscreen by Dagon
- Joshua - Destroyed by Dagon with her power
- Dagon - Incinerated by Castiel, powered up by Jack (Kelly and Lucifer's nephilim)
Twigs & Twine & Tasha Banes
- Tasha Banes - Heart cut out by the Demon Borrower Witch
- Demon Borrower Witch - Shot by Dean with a witch-killing bullet
- Andy doll - Destroyed when Dean killed the Demon Borrower Witch
- Tasha Banes doll - Destroyed when Dean killed the Demon Borrower Witch
- Rick doll - Destroyed when Dean killed the Demon Borrower Witch
- Alicia Banes - Stabbed by the Tasha Banes doll, mortally wounding her. Max later created a twig doll of her using her heart, which retains the original Alicia's memories.
There's Something About Mary
- Eileen Leahy - Mauled to death by a Hellhound under Ketch's control. She later returned as a ghost and was revived by Sam with a spell.
- Rick - Throat slit by Mary, who was brainwashed by Toni.
Who We Are
- Lester - Killed offscreen by Mary.
- Roy (hunter) - Shot by a British Man of Letters.
- Toni Bevell - Throat slit offscreen by Arthur Ketch
- Arthur Ketch - Shot in the head by Mary. He was revived by Rowena's death-cheating spell
- Dr. Hess - Shot in the head by Jody.
All Along the Watchtower
- Rowena - Head stomped on by Lucifer, then set on fire (offscreen). Revived
- Crowley - Stabbed himself with an angel blade to complete the ritual to close the rift.
- Kelly Kline - Gave birth to Jack, killing her in a flash of light.
- Castiel - Stabbed from behind by Lucifer with an angel blade. He was later revived by a mysterious entity
Lost and Found
- Miriam - Stabbed by Sam with an angel blade
The Rising Son
- Sierra - Stabbed from behind by Sam with an angel blade
- Harrington - Angel blade thrown at his neck by Dean
- Alternate Lucifer - Is mentioned to have been destroyed by Alternate Michael
- Dede - Blood sucked from her brain by an unnamed wraith
- Missouri Moseley - Blood sucked from her brain by the wraith
- Wraith - Stabbed by Dean with a silver blade
The Big Empty
- Wes Bailey - Stabbed by Buddy with a knife, posing as his wife Erica
- Gloria Simon - Killed partially offscreen by Buddy, posing as her son Scott
- Buddy - Shot by Sam with a silver bullet
- Evan - Head drilled by Dr. Meadows's ghost
- Shawn Raider - Head drilled by Dr. Meadows's ghost while possessed by him
- Dr. Avery Meadows (ghost) - Destroyed when Dean burned his masks which he was tied to.
- Dean Winchester - Injected himself with poison so he could temporarily die and free the ghosts of those killed by Meadows. Once everything is done, Billie (who is now Death) brought him back.
- Deputy Carl Phillips - Bitten offscreen by Dave
- Lenny - Accidentally blasted by Jack with his power, hitting his head on a pillar
- Dave Mather - Head blown off by Joe Phillips with a shotgun
The Scorpion and the Frog
- Grab - Stabbed by Shrike with the demon-killing knife
- Luther Shrike - Decapitated by Bart
- Bart - Incinerated when Alice burned his bones
The Bad Place
- Derek Swan - Smote offscreen by an angel
- Male angel - Set by Jack with his power to stab himself with an angel blade
- Female angel - Destroyed by Jack and Kaia with their combined power when they opened a dimensional portal
- Ed (werewolf) - Shot by Claire with a silver bullet
- Ed's partner - Stabbed by Claire with a silver knife
- Luis Fernando - Butchered by the Harvester
- Marlon - Presumably decapitated by Donna
- The Harvester - Stabbed in the heart by Donna with a meat cleaver
- Clegg - Shot in the back by Dean
Various & Sundry Villains
- Marty - Thrown through a window by Dale under Jamie's love spell
- Dale - Head bashed in by Jamie with a hammer
- Dipper - Smote by Castiel
- Mrs. Plum (zombie) - Shot in the head by Rowena
- Jennie Plum - Stabbed repeatedly by Jamie with a knife under Rowena's Attack Dog spell
- Jamie Plum - Beaten to death by Jennie with a hammer under Rowena's Attack Dog spell
- Magog - Decapitated by Dean with his own sword, which was forged by God
- Gog - Stabbed from behind by Dean with Magog's sword
- Alternate Zachariah - Exploded into dust by Jack
A Most Holy Man
- Antonio Miele - Killed offscreen by Mr. Cromarty
- Margaret Astor - Shot in the back by Mr. Cromarty
- Santino Scarpatti - Shot by Mr. Cromarty
- Mr. Cromarty - Shot by Sam
- Cousin Simple - Stabbed by the Ghost Kid
- Cosgood Creeps - Decapitated and sliced in two by the Ghost Kid
- Ghost Kid - Put to rest when Sam burned the pocket knife he was tied to
- Sandy Porter - Killed when Diego transferted Yokoth into her. (Unlike when Hitler possessed Nauhaus) Set in the past
- Diego Avila - Eaten by Yokoth. (Set in the past)
- Asmodeus's guard - Stabbed by Ketch with the archangel blade
Bring 'em Back Alive
- Father Davis - Exploded into dust by Lucifer
- Asmodeus - Incinerated by Gabriel with his power
- Elizabeth Mahler - Spontaneously combusted by Rowena
- James Melford - Spontaneously combusted by Rowena
- Martin (reaper) - Spontaneously combusted by Rowena
- Bernard - Strangled by Dean
- Fenrir - Stabbed in the heart by Gabriel with a sword designed to kill him
- Alternate Balthazar - Is mentioned to be killed by Jack
- Narfi - Stabbed by Gabriel with a sword designed to kill him
- Alternate Kevin Tran - Blew himself up with an angelic suicide bomb to kill survivors and break Jack's spirit
- Jacob - Blown up by Kevin's suicide bomb
- Sleipnir - Stabbed in the heart by Gabriel with a sword designed to kill him
- Loki - Stabbed in the heart by Gabriel with a sword designed to kill him
Beat the Devil
- Floyd - Blood sucked by vampires
- Sam Winchester - Throat torn out by a vampire. He was revived by Lucifer
- Torturer angel - Stabbed by Dean with an angel blade
- Alternate Castiel - Stabbed by Castiel with an angel blade
- Andy - Killed when Alternate Michael crashed into him in meteor form
- Gabriel - Stabbed by Alternate Michael with an archangel blade
Let the Good Times Roll
- Maggie - Skull crushed offscreen by Lucifer. She was later revived by Lucifer to gain Jack's trust
- Lucifer - Stabbed by Dean with the archangel blade, powered up by Michael inside him. He is later revived by Chuck
Stranger in a Strange Land
- Kipling - Stabbed by Sam with the demon-killing knife
Gods and Monsters
- Lydia Crawford - Smote by Alternate Michael
- Arty Nielson - Head bashed in by Nick with a hammer for being forced to keep quiet about his family's deaths
- Laura - Youth stolen by a witch with a magic amulet. She was later revived when Jack destroyed the amulet
- Jordan MacNeel (ghost) - Destroyed when Sam burned the keychain he was tied to.
- Neil - Head bashed in by Dean with a metal bookend
- Winston Mathers - Throat torn out semi-offscreen by Vance
- Miles - Throat torn out offscreen by Vance
- Musca - Shot by Sam
- Vance (zombie) - Put in a grave and stabbed in the heart with a wooden stake by Dean or Jack, offscreen. (Note: In life, Harper killed him then raised him as a zombie)
- Frank Kellogg - Head bashed in by Nick with a hammer because Abraxas had possessed him to kill his family
- Jack Kline - Died as a result of Lucifer taking his grace, as an archnephilim needs archangel grace to survive. He was revived by Lily Sunder with Castiel's help, using a small fraction of his soul to sustain his body.
- Lily Sunder - Sacrificed her life with the spell to revive Jack. This act allows her into Heaven, as beforehand Anubis told her she'd go to hell.
- Brett - Decapitated by Sam
- Melanie - Decapitated by Sam
- Tiger - Killed offscreen by a shapeshifter who then impersonated him.
- Tiger Impersonator - Destroyed by Jack with a wave of magic.
- Abraxas - Stabbed by Nick with an angel blade as revenge for killing his family.
- Jeff - Stabbed by Nick with an angel blade while possessed by Abraxas
Prophet and Loss
- Woman - Wrists slit by Tony
- Alan - Throat slit by Tony
- Tony - Shot himself in the neck
- Bart Kemp - Chopped in half by Terry with Chrysayor
- Terry - Shot in the back by Dean
- John Wayne Gacy (ghost) - Destroyed when Sam burned his cigar box in the fireplace. (Was briefly released from hell as a ghost again)
- Zachariah - Stabbed in the heart by Sam with an angel blade. (Note: This is due to altering of history so Zachariah is alive; his original death is later restored along with the rest of the timeline)
- Dennis Barron - Eaten by Noah
- Noah Ophis - Decapitated by Jack with a silver blade
- Maggie - Smote by Alternate Michael
- Alternate Michael - Incinerated by Jack with the power of his soul
Peace of Mind
- Conrad Martin - Head exploded by Chip
- Justin Smith - Head exploded by Chip
- Felix the snake - Turned to ash by Jack so he could be reunited with Noah in Heaven (despite Noah spending his afterlife asleep in the Empty due to being a demigod)
Don't Go in the Woods
- Barbara - Eaten by Henry Parker
- Henry Parker - Stabbed in the heart by Sheriff Mason with a silver knife
- Nick - Burned by Jack with his power.
- Mary Winchester - Accidentally destroyed by Jack with his power. (Confirmed in the following episode)
Jack in the Box
- Harrison Tate - Turned to salt by Jack
- Duma - Stabbed by Castiel with an angel blade
- Jack Kline - Smote by Chuck snapping his fingers. He was later revived by Billie
Back and to the Future
- Rachel - Killed in front of a mirror by Bloody Mary
- Kimiko - Smote offscreen by Chuck
- Nan - Stabbed repeatedly in the stomach by Rob who was possessed by Francis Tumblety
- Arthur Ketch - Heart pulled out and crushed by Ardat
- Malfayan - Stabbed by Castiel with an angel blade
- Ardat - Stabbed in the back by Belphegor with an angel blade
- Belphegor - Smote by Castiel
- Rowena - Stabbed by Sam with a knife as a sacrifice for her spell to send all the evil souls and demons to hell (along with her, as she jumps into hell). This time her death is final, as she removed her resurrection spell for this. After death she becomes queen of hell.
- Alternate Dean Winchester - Neck snapped by Sam using telekinesis (Alternate Reality)
- Susie Martin - Blood sucked by Billy accidentally
- Billy Whitman - Decapitated by Dean with a machete (which he accepted, knowing he couldn't control his bloodlust)
- Julie - Heart torn out by Josh
- Camper Girl 3 - Heart torn out by Josh
- Alternate Dean Winchester - Burned by Lucifer (Alternate Reality)
- Josh May - Shot by Andy with a silver bullet
- Andy May - Shot himself in the heart with a silver bullet
- Alternate Sam Winchester - Stabbed by Dean (Alternate Reality)
- Jacinda - Killed by Rowena's spell to kill anyone who enters her room (except Sam). Returned as a ghost
- Sheriff Alden Roy - Stabbed by Castiel with an angel blade
- Emily - Shot by Dean
- Jacinda's mother - Killed by Sam with a hex bag and magic spell
- Jacinda (ghost) - Destroyed when Dean burned her body
- Angela Sullivan - Blood drained by the Marid
- Marid - Decapitated by Dean with a saw
- Lee Webb - Stabbed by Dean with a broken pool cue
Our Father, Who Aren't In Heaven
- Lilith - Destroyed in a flash of light by Michael
- Ashley Monroe - Destroyed along with Lilith by Michael (was already mortally wounded from Lilith falling on spikes)
- Benny - Is mentioned to be torn apart by vampires in Purgatory. (Note: He was already dead and spending his afterlife in Purgatory; his current afterlife, if any, is unknown)
- Claire Novak - Is mentioned to be killed by vampires. (Alternate future where Chuck was imprisoned)
- Donna Hanscum - Is mentioned to be killed by monsters. (Alternate future)
- Alex Jones - Is mentioned to be killed by monsters. (Alternate future)
- Patience Turner - Is mentioned to be killed by monsters. (Alternate future)
- Eileen Leahy - Is mentioned to be killed by monsters. (Alternate future)
- Jody Mills - Blood sucked by Dean, in vampire form. (Alternate future)
- Sam Winchester - Decapitated by Alternate Bobby, as he was turned into a vampire. (Alternate future)
The Heroes' Journey
- Cutty - Blown up by Garth with C4
- Killer Wraith - Blown up by Garth with C4
- Jamaica Djinn - Blown up by Garth with C4
- Maul - Head split vertically in two by Garth with a machete
- Leonard - Hit by a truck after losing all his luck in Fortuna's game of pool
- Vic Sariel - Heart torn out and eaten by Jack
- Joey Six - Died of cancer after losing all his luck to Dean in Fortuna's game of pool
- Kabaiel - Stabbed by Castiel with an angel blade
- Dark Kaia - Destroyed along with the Bad Place by Chuck
- Merle - Killed by Billie with Death's Scythe
- Radio Shed clerk - Destroyed along with Earth 2 by Chuck with flaming meteors
- Gregor - Stabbed by Sam with an angel blade
- Conner Todd - Killed offscreen by Sylvia
- Brother Rudy - Killed offscreen by Sylvia
Drag Me Away (From You)
- Travis Johnson - Stabbed himself with a broken bottle due to hallucinations caused by Baba Yaga
- Virgil - At some point between Galaxy Brain and this episode, was destroyed along with the world he was trapped in by Chuck
- Geneveive Padalecki - At some point, destroyed along with her world by Chuck
- Serge Ladouceur - At some point, destroyed along with his world by Chuck
- Baba Yaga - Destroyed when Dean smashed the stone on her ring with his gun
- Stevie - Erased by Chuck. She was later revived by Jack
- Eileen Leahy - Erased by Chuck. She was later revived by Jack
- Lily - Erased by Chuck. She was later revived by Jack
- Dana - Erased by Chuck. She was later revived by Jack
- Jules - Erased by Chuck. She was later revived by Jack
- Alternate Charlie Bradbury - Erased by Chuck. She was later revived by Jack
- Alternate Bobby Singer - Erased by Chuck. He was later revived by Jack
- Donna Hanscum - Erased by Chuck. She was later revived by Jack
- Castiel - Absorbed into the Empty by Cosmic Entity. Implied to be revived by Jack
- Billie - Absorbed into the Empty by Cosmic Entity
- All humans, monsters, and animals on Earth except Sam, Dean, and Miracle - Erased by Chuck. Were later revived by Jack
Inherit the Earth
- Miracle - Erased by Chuck. Was later revived by Jack
- Adam Milligan - Is mentioned to be killed by Chuck along with the rest of humanity. He was later revived by Jack
- Betty - Stabbed by Lucifer with an angel blade. As the first reaper to die after Billie's death, she is revived as the new Death.
- Betty - Turned to ash by Lucifer snapping his fingers
- Lucifer - Stabbed by Michael with an archangel blade
- Michael - Destroyed in an explosion of energy by Chuck
Note: Chuck (God) does not die onscreen, but he is drained of his power and turned human by Jack, meaning he, like any mortal humans alive by the story's end, will eventually die of old age. It is likely this will occur before the final scene of the final episode.
- Lyle - Blood drained offscreen by vampires
- Jenny - Decapitated by Sam
- Dean Winchester - Impaled on a spike by a vampire. On death he went to Heaven and reunited with Bobby
- Sam Winchester - Died of old age. On death he went to Heaven and reunited with Dean
- Total - ???
- Season One -
- Season Two -
- Season Three -
- Season Four -
- Season Five -
- Season Six -
- Season Seven -
- Season Eight -
- Season Nine -
- Season Ten -
- Season Eleven -
- Season Twelve -
- Season Thirteen -
- Season Fourteen -
- Season Fifteen -